Ahmed Masroor, Naqvi Baqir S, Shoaib Muhammad Harris, Shaikh Dilnawaz, Hashmi Khursheed
Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi.
Pak J Pharm Sci. 2002 Jan;15(1):9-14.
Pediatric bacterial infections are very rapidly growing in developing countries. Bacterial resistance to antimicrobial agents is a serious problem in the treatment of Pediatric bacterial infection. One of the most effective ways to control antibiotic resistance, is the development of surveillance programs. For this purpose isolates were collected from paediatric wards of different hospitals. The result shows that isolates were highly resistant against majority of selected antibiotics with increase in the MIC's. In Penicillin group, the most effective agent is Amoxicillin and Clavulanic acid, more than 90% isolates of Staphylococcus aureus were susceptible while other agents, as Cloxacillin, Ampicillin and Amoxicillin alone shows moderate activity against Staphylococcus aureus and Escherichia coli.
在发展中国家，儿科细菌感染正迅速增加。细菌对抗菌药物的耐药性是治疗儿科细菌感染的一个严重问题。控制抗生素耐药性最有效的方法之一是开展监测项目。为此，从不同医院的儿科病房收集了分离株。结果显示，随着最低抑菌浓度（MIC）的增加，分离株对大多数选定抗生素具有高度耐药性。在青霉素组中，最有效的药物是阿莫西林克拉维酸，超过90%的金黄色葡萄球菌分离株对其敏感，而其他药物，如氯唑西林、氨苄西林和单独使用的阿莫西林，对金黄色葡萄球菌和大肠杆菌显示出中等活性。
