Rotunda Adam M, Avram Mathew M, Avram Alison Sharpe
Department of Dermatology, University of Southern California Keck School of Medicine, Bennett Surgery Center, Santa Monica, CA 90404, USA.
J Cosmet Laser Ther. 2005 Dec;7(3-4):147-54. doi: 10.1080/14764170500430234.
Cellulite describes the cutaneous dimpling of the thighs, buttocks, and hips that is seen predominately in women. Current evidence suggests that structural differences in fat architecture between the sexes account for its appearance. Mesotherapy, a method of delivering medication locally with the use of numerous cutaneous injections, has recently become a popular method to purportedly treat the condition.
An overview of cellulite and adipocyte physiology, with a literature review and appraisal of compounds commonly used in mesotherapy.
Experimental studies using individual mesotherapy ingredients for other conditions suggest a number of mechanisms, including lipolysis, disrupting connective tissue and augmenting circulation, which may theoretically improve cellulite. Peer-reviewed studies have not evaluated whether these effects translate clinically.
Until further studies are performed, patients considering mesotherapy for cellulite must be aware that the substances currently being injected to treat this cosmetically disturbing, but medically benign, condition have not been thoroughly evaluated for safety or efficacy.
橘皮组织指的是主要出现在女性大腿、臀部和髋部的皮肤凹陷。目前的证据表明，男女脂肪结构的差异导致了其出现。中胚层疗法是一种通过多次皮内注射进行局部给药的方法，最近已成为一种据称可治疗该病症的流行方法。
对橘皮组织和脂肪细胞生理学进行概述，并对中胚层疗法中常用的化合物进行文献综述和评估。
使用中胚层疗法的个别成分治疗其他病症的实验研究表明了多种机制，包括脂肪分解、破坏结缔组织和促进循环，从理论上讲，这些机制可能改善橘皮组织。同行评审研究尚未评估这些作用是否能转化为临床效果。
在进行进一步研究之前，考虑采用中胚层疗法治疗橘皮组织的患者必须意识到，目前用于治疗这种虽在美容方面令人困扰但医学上无害的病症的注射物质，其安全性和有效性尚未得到充分评估。
