Pavicic Tatjana, Borelli Claudia, Korting Hans Christian
Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Germany.
J Dtsch Dermatol Ges. 2006 Oct;4(10):861-70. doi: 10.1111/j.1610-0387.2006.06041.x.
Cellulite or so called orange peel skin affects 80-90 % of all females. It is not considered as a pathological condition but as aesthetically disturbing dimpling of the skin seen most commonly on the thighs and buttocks. Despite its high prevalence, there have been only a few scientific investigations into the pathophysiology of cellulite reflected in the medical literature. A lack of knowledge regarding specific aetiopathogenetic factors and pathogenesis at large currently limits treatment options. The preferred hypotheses about the origin of cellulite include: gender specific dimorphic skin architecture, altered connective tissue septae, vascular changes and inflammatory processes. The most widely discussed management options include: attenuation of aggravating factors, physical procedures including laser therapy and application of topical incorporating actives. The latter approach has been evidence-based with respect to caffeine liposomal cream and retinol cream.
橘皮组织，即所谓的“橙皮皮肤”，影响着80%至90%的女性。它不被视为一种病理状况，而是一种在美学上令人困扰的皮肤凹陷，最常见于大腿和臀部。尽管其发病率很高，但医学文献中关于橘皮组织病理生理学的科学研究却很少。目前，对特定病因和发病机制缺乏了解限制了治疗选择。关于橘皮组织成因的主流假说包括：性别特异性的双态皮肤结构、结缔组织间隔改变、血管变化和炎症过程。讨论最多的治疗方法包括：减轻加重因素、物理治疗（包括激光治疗）以及使用含有活性成分的外用制剂。就咖啡因脂质体乳膏和视黄醇乳膏而言，后一种方法有循证依据。
