Freedman Bruce M, Balakrishnan Toral P, Reedy Edward A
Plastic Surgery Associates of Northern Virginia, McLean, VA 22102, USA.
J Cosmet Laser Ther. 2005 Dec;7(3-4):191-5. doi: 10.1080/14764170500369960.
Ablative and nonablative laser treatments have established themselves independently in the rejuvenation of aging skin. This study was designed to determine the effects of sequential nonablative and ablative laser treatments on facial skin.
Twelve patients, ages 32-56 years, with skin phototypes I-IV, received three treatments spaced six weeks apart. Each treatment consisted of one pass with 1319-nm Nd:YAG laser at 16 J/cm(2), 50 ms pulse duration. This was immediately followed by one pass of 2940-nm Er:YAG laser at 5 J/cm(2). Photographs and biopsies were taken prior to the first treatment and following the third treatment.
Clinical improvements in facial skin tone and texture, acne scarring and dyschromia were noted in all patients. Histologic changes included a more compact epidermal granular layer and lamellar collagen formation with decreased solar elastosis in the dermis. Compared to controls, treated skin had a thicker, more homogeneous papillary dermis.
The sequential use of nonablative and superficial ablative laser treatments clinically and histologically improved photodamaged and chronologically aged skin. This occurred with minimal recovery and little morbidity, demonstrating this laser application to be a safe and effective method for facial rejuvenation.
剥脱性和非剥脱性激光治疗已在衰老皮肤年轻化领域各自确立了地位。本研究旨在确定非剥脱性和剥脱性激光序贯治疗对面部皮肤的影响。
12例年龄在32 - 56岁、皮肤光型为I - IV型的患者,接受了三次间隔六周的治疗。每次治疗包括一次1319纳米掺钕钇铝石榴石激光照射,能量密度为16焦耳/平方厘米,脉冲持续时间为50毫秒。随后立即进行一次2940纳米铒激光照射,能量密度为5焦耳/平方厘米。在第一次治疗前和第三次治疗后拍摄照片并进行活检。
所有患者面部肤色、质地、痤疮瘢痕和色素沉着均有临床改善。组织学变化包括表皮颗粒层更致密、板层状胶原形成以及真皮中日光性弹力纤维变性减少。与对照组相比,治疗后的皮肤乳头层真皮更厚且更均匀。
非剥脱性和浅表剥脱性激光序贯治疗在临床和组织学上改善了光损伤和自然老化的皮肤。恢复时间最短且发病率低,表明这种激光应用是一种安全有效的面部年轻化方法。