Alkady E A M, Ahmed H M, Tag L, Abdou M A
Rheumatology and Rehabilitation Department, Assiut University Hospitals, Assiut University, Assiut, Egypt.
Z Rheumatol. 2011 Sep;70(7):602-8. doi: 10.1007/s00393-011-0834-2.
Recent data provided evidence on the implication of the adipocytokines adiponectin, visfatin, and resistin in inflammation, immune response, and tissue destruction and revealed several links between them and arthritis.
The purpose of this study was to assess the levels of adiponectin, visfatin, and resistin in serum and synovial fluid of patients with rheumatoid arthritis (RA) and their relationship with disease activity.
A total of 70 female patients with RA and 30 age- and sex-matched healthy controls were enrolled. The clinical activity of RA patients was assessed according to the 28 joint count Disease Activity Score and patients were classified into two groups: 39 patients with active disease (group A) and 31 patients in remission (group B). Synovial fluid was obtained by arthrocentesis of the affected knee joints from 39 patients with active disease. Serum adiponectin, visfatin, and resistin concentrations were measured in RA patients and controls, while a specific enzyme-linked immunosorbent assay was used to measure the synovial concentrations of adiponectin, visfatin, and resistin in the group of patients with active RA.
Serum levels of adiponectin and visfatin were significantly higher in all RA patients and patients with active disease compared to the control group and patients in remission. No significant difference was observed in the resistin level between patients and controls. Serum and synovial adiponectin and visfatin were positively correlated with DAS28-ESR in RA patients with active disease.
Our data demonstrated that adiponectin and visfatin are related to disease activity in RA patients and might be involved in the progression of RA. The English full-text version of this article is available at SpringerLink (under "Supplemental").
近期数据证明了脂肪细胞因子脂联素、内脂素和抵抗素在炎症、免疫反应及组织破坏中的作用，并揭示了它们与关节炎之间的若干联系。
本研究旨在评估类风湿关节炎（RA）患者血清及滑液中脂联素、内脂素和抵抗素的水平及其与疾病活动度的关系。
共纳入70例女性RA患者及30例年龄和性别匹配的健康对照。根据28个关节计数疾病活动评分评估RA患者的临床活动度，并将患者分为两组：39例疾病活动患者（A组）和31例病情缓解患者（B组）。通过关节穿刺从39例疾病活动患者的患膝关节获取滑液。测定RA患者及对照血清中脂联素、内脂素和抵抗素的浓度，同时采用特异性酶联免疫吸附测定法测定疾病活动RA患者组滑液中脂联素、内脂素和抵抗素的浓度。
与对照组及病情缓解患者相比，所有RA患者及疾病活动患者血清中脂联素和内脂素水平显著更高。患者与对照之间抵抗素水平未观察到显著差异。疾病活动RA患者血清及滑液中的脂联素和内脂素与DAS28-ESR呈正相关。
我们的数据表明，脂联素和内脂素与RA患者的疾病活动度相关，可能参与RA的进展。本文的英文全文版本可在SpringerLink（“补充材料”下）获取。
