Yashiro Masakazu, Sunami Takeshi, Hirakawa Kosei
The Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
Dig Dis Sci. 2005 Dec;50(12):2224-30. doi: 10.1007/s10620-005-3039-1.
Even among gastric carcinoma cases with a similar extent of lymphatic invasion, the number of diseased lymph nodes may vary. Other factors might also contribute to the process of lymphangitic metastasis. Primary gastric tumors with the same extent of pathologic lymphatic invasion were studied in 78 patients. We investigated the correlation between CD54 expression on cancer cells and clinicopathologic features. Decreased CD54 expression on cancer cells was significantly correlated with the number of involved lymph nodes and the extent of lymph node spread. The number of diseased lymph nodes was associated with the prognosis of patients with gastric carcinoma. The CD54-negative group had a significantly worse prognosis than the CD54-positive group. These findings suggested that CD54 expression is predictive for lymphatic spread and prognosis in human gastric carcinoma.
即使在淋巴侵犯程度相似的胃癌病例中，受累淋巴结的数量也可能有所不同。其他因素也可能促成淋巴管转移过程。我们对78例具有相同病理淋巴侵犯程度的原发性胃肿瘤进行了研究。我们调查了癌细胞上CD54表达与临床病理特征之间的相关性。癌细胞上CD54表达降低与受累淋巴结数量及淋巴结扩散程度显著相关。受累淋巴结的数量与胃癌患者的预后相关。CD54阴性组的预后明显比CD54阳性组差。这些发现表明，CD54表达可预测人类胃癌的淋巴转移和预后。
