Brungs Daniel, Aghmesheh Morteza, Vine Kara L, Becker Therese M, Carolan Martin G, Ranson Marie
Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, 2522, Australia.
School of Biological Sciences, University of Wollongong, Wollongong, 2522, Australia.
J Gastroenterol. 2016 Apr;51(4):313-26. doi: 10.1007/s00535-015-1125-5. Epub 2015 Oct 1.
Gastric cancer is a significant global health problem. It is the fifth most common cancer and third leading cause of cancer-related death worldwide (Torre et al. in CA Cancer J Clin 65(2):87-108, 2015). Despite advances in treatment, overall prognosis remains poor, due to tumour relapse and metastasis. There is an urgent need for novel therapeutic approaches to improve clinical outcomes in gastric cancer. The cancer stem cell (CSC) model has been proposed to explain the high rate of relapse and subsequent resistance of cancer to current systemic treatments (Vermeulen et al. in Lancet Oncol 13(2):e83-e89, 2012). CSCs have been identified in many solid malignancies, including gastric cancer, and have significant clinical implications, as targeting the CSC population may be essential in preventing the recurrence and spread of a tumour (Dewi et al. in J Gastroenterol 46(10):1145-1157, 2011). This review seeks to summarise the current evidence for CSC in gastric cancer, with an emphasis on candidate CSC markers, clinical implications, and potential therapeutic approaches.
胃癌是一个重大的全球健康问题。它是全球第五大常见癌症，也是癌症相关死亡的第三大主要原因（Torre等人，发表于《CA：临床医师癌症杂志》2015年第65卷第2期，第87 - 108页）。尽管治疗取得了进展，但由于肿瘤复发和转移，总体预后仍然很差。迫切需要新的治疗方法来改善胃癌的临床结局。癌症干细胞（CSC）模型已被提出用于解释癌症复发率高以及对当前全身治疗产生耐药性的原因（Vermeulen等人，发表于《柳叶刀肿瘤学》2012年第13卷第2期，第e83 - e89页）。在包括胃癌在内的许多实体恶性肿瘤中都已鉴定出癌症干细胞，并且具有重要的临床意义，因为靶向癌症干细胞群体可能对于预防肿瘤的复发和扩散至关重要（Dewi等人，发表于《胃肠病学杂志》2011年第46卷第10期，第1145 - 1157页）。本综述旨在总结目前胃癌中癌症干细胞的证据，重点关注候选癌症干细胞标志物、临床意义和潜在的治疗方法。
