Kennedy B J
Department of Medicine, University of Minnesota Medical School, Minneapolis.
Semin Oncol. 1992 Jun;19(3 Suppl 9):21-6.
The evolution of hydroxyurea as a chemotherapeutic agent has been unique. Hydroxyurea inhibits synthesis of DNA, has antitumor activity, and is myelosuppressive. It has attained a significant role in the management of chronic myelogenous leukemia. A nonrandomized comparison of busulfan and hydroxyurea concluded that hydroxyurea was the preferable agent in the treatment of chronic myelogenous leukemia and was associated with less life-threatening toxicity. Because of its systemic effects, hydroxyurea is also used in the treatment of polycythemia and psoriasis.
羟基脲作为一种化疗药物的发展历程独具特色。羟基脲可抑制DNA合成，具有抗肿瘤活性，且有骨髓抑制作用。它在慢性粒细胞白血病的治疗中发挥了重要作用。一项关于白消安和羟基脲的非随机对照研究得出结论，羟基脲是治疗慢性粒细胞白血病的更优药物，且其毒性对生命的威胁较小。由于其全身作用，羟基脲还用于治疗真性红细胞增多症和银屑病。
