Hosovski E, Vidaković A, Milić S
Dr. Dragomir Karajovitch Institute of Occupational Medicine and Radiological Protection, Belgrade.
Srp Arh Celok Lek. 1992 Jan-Feb;120(1-2):34-8.
Workers working in copper alloy factories (n = 40) who are professionally exposed to smoke and dust of copper, zinc, lead and cadmium and workers who are not exposed to toxic noxae (n = 15) were perorally administrated penicillamine for three days in order to evaluate deposits of these metals in their organisms. On the basis of the results obtained after penicillamine administration it was concluded that this substance can be useful in the evaluation of the presence of copper in workers. Penicillamine mobilisatory effect on lead and zinc in the organism was also proved. Because of competitive relations between copper and zinc (copper was a dominant noxa) it was not possible to evaluate the internal zinc presence. The mobilisatory effect of penicillamine on cadmium in the organism was not observed.
对在铜合金工厂工作且职业性接触铜、锌、铅和镉烟尘的40名工人以及未接触有毒有害物质的15名工人口服青霉胺三天，以评估这些金属在他们体内的沉积情况。根据服用青霉胺后获得的结果得出结论，该物质在评估工人体内铜的存在情况时可能有用。还证实了青霉胺对体内铅和锌的动员作用。由于铜和锌之间存在竞争关系（铜是主要的有害物质），因此无法评估体内锌的存在情况。未观察到青霉胺对体内镉的动员作用。
