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[去铁胺对铝加工工人的影响]

[The effect of desferrioxamine in aluminum-processing workers].

作者信息

Hosovski E, Vidaković A

机构信息

Dr. Dragomir Karajović Institute of Occupational and Radiological Xenthex, Belgrade.

出版信息

Srp Arh Celok Lek. 1990 Sep-Oct;118(9-10):341-5.

PMID:2102549
Abstract

The presence of aluminium, iron, copper, zinc and manganum was evaluated in workers who were professionally exposed to aeropollution, especially to metals i.e. aluminium (n = 25) and workers who were not exposed to toxic noxe (= 18). The instantaneous presence of metal concentrations in the blood and urine was not a sufficient sign in the evaluation of the body burden. The intramuscular administration of desferrioxamine had a significant effect on the mobilization of iron- and aluminium-depots. On the basis of increased aluminium elimination, changed values of total transferrin (TIBC) and increased activity of alkaline phosphatase in the serum provoked by desferrioxamine it was possible to evaluate the presence of aluminium in exposed workers. According to the obtained results desferrioxamine had no effect on copper, zinc and manganum in the organism of these workers.

摘要

对职业性接触空气污染尤其是金属(即铝,n = 25)的工人以及未接触有毒有害物质的工人(n = 18)体内铝、铁、铜、锌和锰的含量进行了评估。血液和尿液中金属浓度的即时检测结果不足以作为评估体内负荷的指标。肌肉注射去铁胺对铁和铝储存库的动员有显著影响。根据去铁胺引起的铝排泄增加、总转铁蛋白(TIBC)值的变化以及血清中碱性磷酸酶活性的增加,可以评估接触工人体内铝的存在情况。根据所得结果,去铁胺对这些工人机体中的铜、锌和锰没有影响。

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