Comi Anne M, Johnston Michael V, Wilson Mary Ann
Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University, Baltomore, MD 21205, USA.
J Child Neurol. 2005 Dec;20(12):980-3. doi: 10.1177/08830738050200120901.
Cerebral palsy in humans results from a diverse group of disorders that produce nonprogressive motor impairments in the developing brain. Stroke is an important cause of hemiparetic cerebral palsy in neonates and young children. We recently developed a new immature mouse model of stroke that demonstrates seizures, the severity of which correlates with brain injury. This model has strengths compared with other immature rodent models of ischemic injury, such as relative technical ease and the presence of seizures, as is seen in humans. This model also has relative weaknesses, such as the inability to titrate the severity of the injury with different periods of hypoxia. In addition, more work is needed to delineate the long-term consequences of the insult in this new model.
人类的脑瘫源于多种疾病，这些疾病会在发育中的大脑中产生非进行性运动障碍。中风是新生儿和幼儿偏瘫型脑瘫的一个重要原因。我们最近开发了一种新的未成熟小鼠中风模型，该模型会出现癫痫发作，其严重程度与脑损伤相关。与其他未成熟啮齿动物缺血性损伤模型相比，该模型具有一些优势，比如技术相对简便，且会出现癫痫发作，这与人类情况相似。该模型也有相对的弱点，比如无法通过不同时长的缺氧来调节损伤的严重程度。此外，还需要开展更多工作来明确这种新模型中损伤的长期后果。
