新生儿惊厥：将新疗法从实验室转化到保温箱中的争议和挑战。
Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette.
机构信息
Department of Pediatrics, Section of Pediatric Neurology, University of Colorado School Of Medicine, Children's Hospital Colorado, 13123 East 16th Ave, B155, Aurora, CO 80045, USA.
出版信息
Eur J Neurosci. 2012 Jun;35(12):1857-65. doi: 10.1111/j.1460-9568.2012.08140.x.
Abstract
Neonatal seizures have unique properties that have proved challenging for both clinicians and basic science researchers. Clinical therapies aimed at neonatal seizures have proven only partially effective and new therapies are slow to develop. This article will discuss neonatal seizures within the framework of the barriers that exist to the development of new therapies, and the challenges inherent in bringing new therapies from the bench to the bedside. With the European Union and USA creating national collaborative project infrastructure, improved collaborative resources should advance clinical research on urgently needed new therapies for this disorder.
摘要
新生儿癫痫具有独特的特征，这给临床医生和基础科学研究人员都带来了挑战。针对新生儿癫痫的临床治疗方法已被证明只有部分有效，新的治疗方法开发进展缓慢。本文将在新疗法发展所面临的障碍以及将新疗法从实验室推向临床所固有的挑战的框架内讨论新生儿癫痫。随着欧盟和美国建立国家合作项目基础设施，改善合作资源应能促进对这种疾病急需的新疗法的临床研究。
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