Soltani Mehnam, MacGowan Alasdair P, Lovering Andrew M
Bristol Centre for Antimicrobial Research and Evaluation, Department of Medical Microbiology, Southmead Hospital, North Bristol NHS Trust, Bristol BS10 5NB, UK.
Int J Antimicrob Agents. 2006 Feb;27(2):165-7. doi: 10.1016/j.ijantimicag.2005.10.018. Epub 2006 Jan 18.
Ertapenem is a new carbapenem with a broad spectrum of activity and an extended half-life, permitting once daily administration. Although high-performance liquid chromatography (HPLC) methods have been described for ertapenem, these are complex and involve column switching and thus this type of assay may not suitable for use in routine clinical microbiology laboratories. In this study we report a rapid, straightforward HPLC method for the detection of ertapenem in human serum.
厄他培南是一种新型碳青霉烯类抗生素，具有广谱抗菌活性和较长的半衰期，允许每日给药一次。虽然已经有针对厄他培南的高效液相色谱（HPLC）方法报道，但这些方法很复杂，涉及柱切换，因此这类检测方法可能不适用于常规临床微生物实验室。在本研究中，我们报告了一种快速、简便的HPLC方法，用于检测人血清中的厄他培南。
