Kozuma Kazuya, Tsuchiya Shigemi, Kohori Jun, Hase Tadashi, Tokimitsu Ichiro
Health Care Research Laboratories, Kao Corporation, Tokyo, Japan.
Hypertens Res. 2005 Sep;28(9):711-8. doi: 10.1291/hypres.28.711.
A water-soluble green coffee bean extract (GCE) has been shown to be effective against hypertension in both spontaneously hypertensive rats and humans. This multicenter, randomized, double-blind, placebo-controlled, parallel group study evaluated the dose-response relationship of GCE in 117 male volunteers with mild hypertension. Subjects were randomized into four groups: a placebo and three drug groups that received 46 mg, 93 mg, or 185 mg of GCE once a day. After 28 days, systolic blood pressure (SBP) in the placebo, 46 mg, 93 mg, and 185 mg groups was reduced by -1.3+/-3.0 mmHg, -3.2+/-4.6 mmHg, -4.7+/-4.5 mmHg, and -5.6+/-4.2 mmHg from the baseline, respectively. The decreases in SBP in the 93 mg group (p<0.05) and the 185 mg group (p<0.01) were statistically significant compared with the placebo group. Diastolic blood pressure (DBP) in the placebo, 46 mg, 93 mg, and 185 mg groups was reduced by -0.8+/-3.1 mmHg, -2.9+/-2.9 mmHg, -3.2+/-3.2 mmHg, and -3.9+/-2.8 mmHg from the baseline, respectively, and significant effects were observed in the 93 mg group (p<0.05) and the 185 mg group (p<0.01) compared with the placebo group. Both blood pressures were significantly reduced in a dose-related manner by GCE (p<0.001). Adverse effects caused by GCE were not observed. The results suggested that daily use of GCE has a blood pressure-lowering effect in patients with mild hypertension.
一种水溶性绿咖啡豆提取物（GCE）已被证明对自发性高血压大鼠和人类的高血压均有效。这项多中心、随机、双盲、安慰剂对照、平行组研究评估了GCE在117名轻度高血压男性志愿者中的剂量反应关系。受试者被随机分为四组：一组安慰剂组和三组药物组，药物组每天分别服用46毫克、93毫克或185毫克的GCE。28天后，安慰剂组、46毫克组、93毫克组和185毫克组的收缩压（SBP）相对于基线分别降低了-1.3±3.0毫米汞柱、-3.2±4.6毫米汞柱、-4.7±4.5毫米汞柱和-5.6±4.2毫米汞柱。与安慰剂组相比，93毫克组（p<0.05）和185毫克组（p<0.01）的SBP下降具有统计学意义。安慰剂组、46毫克组、93毫克组和185毫克组的舒张压（DBP）相对于基线分别降低了-0.8±3.1毫米汞柱、-2.9±2.9毫米汞柱、-3.2±3.2毫米汞柱和-3.9±2.8毫米汞柱，与安慰剂组相比，93毫克组（p<0.05）和185毫克组（p<0.01）观察到显著效果。GCE使两种血压均以剂量相关的方式显著降低（p<0.001）。未观察到GCE引起的不良反应。结果表明，每日使用GCE对轻度高血压患者具有降压作用。
