Slawecki Craig J
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Behav Neurosci. 2005 Dec;119(6):1477-83. doi: 10.1037/0735-7044.119.6.1477.
The conditions under which age differences in anxiety are observed in rodents are unclear. These studies explored the influence of test condition on anxiety-like behavior in adolescent and adult rats using the light-dark box. Behavior was assessed under different illumination levels (30 or 60 lux) and after brief stress (restraint or bright light). Anxiety-like behavior did not differ in the 30-lux test but was increased in adolescents in the 60-lux test. Restraint increased anxiety-like behavior in adolescents, resulting in elevated anxiety-like behavior relative to adults. Bright light decreased anxiety-like behavior, possibly because of negative contrast or novelty-induced anxiolysis. These studies demonstrate that adolescents display increased anxiety-like behavior when test conditions are more aversive and following exposure to stress.
在啮齿动物中观察到焦虑存在年龄差异的条件尚不清楚。这些研究利用明暗箱探究了测试条件对青春期和成年大鼠焦虑样行为的影响。在不同光照水平（30或60勒克斯）下以及短暂应激（束缚或强光照射）后对行为进行评估。在30勒克斯的测试中，焦虑样行为没有差异，但在60勒克斯的测试中，青春期大鼠的焦虑样行为增加。束缚增加了青春期大鼠的焦虑样行为，导致其焦虑样行为相对于成年大鼠有所升高。强光照射降低了焦虑样行为，这可能是由于负性对比或新奇诱导的抗焦虑作用。这些研究表明，当测试条件更具厌恶性以及暴露于应激后，青春期大鼠会表现出增加的焦虑样行为。
