Numan Michael, Numan Marilyn J, Pliakou Natalia, Stolzenberg Danielle S, Mullins Olivia J, Murphy Jennifer M, Smith Carl D
Department of Psychology, Boston College, Boston, Chestnut Hill, MA 02467, USA.
Behav Neurosci. 2005 Dec;119(6):1588-604. doi: 10.1037/0735-7044.119.6.1588.
The medial preoptic area (MPOA), ventral pallidum (VP), and nucleus accumbens (NA) receive dopaminergic afferents and are involved in maternal behavior. Experiments investigated whether dopamine (DA) receptor antagonism in NA disrupts maternal behavior, determined the type of DA receptor involved, and investigated the involvement of drug spread to VP or MPOA. Injection of SCH 23390 (D1 DA receptor antagonist) into NA of postpartum rats disrupted retrieving at dosage levels that were ineffective when injected into MPOA or VP. Motor impairment was not the cause of the deficit. Injection of eticlopride (D2 DA receptor antagonist) into NA or VP was without effect. Results emphasize the importance of DA action on D1 receptors in NA for retrieval behavior.
内侧视前区（MPOA）、腹侧苍白球（VP）和伏隔核（NA）接受多巴胺能传入纤维并参与母性行为。实验研究了NA中的多巴胺（DA）受体拮抗作用是否会破坏母性行为，确定了所涉及的DA受体类型，并研究了药物扩散到VP或MPOA的情况。将SCH 23390（D1 DA受体拮抗剂）注射到产后大鼠的NA中，在注射到MPOA或VP无效的剂量水平下会破坏找回行为。运动障碍不是缺陷的原因。将依替必利（D2 DA受体拮抗剂）注射到NA或VP中没有效果。结果强调了NA中DA对D1受体作用对于找回行为的重要性。
