Mak Y Erica, Simmons Katharine B, Gitelman Darren R, Small Dana M
The John B. Pierce Laboratory, Yale University School of Medicine, New Haven, CT 06519, USA.
Behav Neurosci. 2005 Dec;119(6):1693-700. doi: 10.1037/0735-7044.119.6.1693.
The authors tested suprathreshold intensity perception of gustatory and olfactory stimuli in a 70-year-old right-handed man following a left posterior insular stroke and compared his results with those of age-matched controls. Both modalities revealed significant differences between left (ipsilateral to lesion) and right (contralateral) ratings of intensity. In both gustation and olfaction, these differences were driven primarily by trends toward increased contralateral sensitivity relative to controls. Intensity changes were most pronounced for unpleasant odors and for tastes perceived strongly as either pleasant (sweet) or unpleasant (salty, bitter). These results show that a left posterior insula lesion may affect taste and olfactory perception similarly by increasing sensitivity contralateral to the lesion. One possible mechanism is release from inhibition at the cortical level.
作者对一名70岁右利手男性在左后岛叶卒中后味觉和嗅觉刺激的阈上强度感知进行了测试，并将其结果与年龄匹配的对照组进行了比较。两种感觉方式均显示出左侧（病变同侧）和右侧（对侧）强度评分之间存在显著差异。在味觉和嗅觉方面，这些差异主要是由相对于对照组对侧敏感性增加的趋势所驱动的。强度变化在不愉快气味以及强烈感知为愉快（甜味）或不愉快（咸味、苦味）的味道方面最为明显。这些结果表明，左后岛叶病变可能通过增加病变对侧的敏感性，以类似的方式影响味觉和嗅觉感知。一种可能的机制是皮质水平的抑制解除。
