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人类脑岛的结构与功能

Structure and Function of the Human Insula.

作者信息

Uddin Lucina Q, Nomi Jason S, Hébert-Seropian Benjamin, Ghaziri Jimmy, Boucher Olivier

机构信息

*Department of Psychology, University of Miami, Coral Gables, Florida, U.S.A.; †Neuroscience Program, Miller School of Medicine, University of Miami, Miami, Florida, U.S.A.; ‡Department of Psychology, Université de Montréal, Montréal, QC, Canada; §Department of Psychology, Université du Québec à Montréal, Montréal, QC, Canada; and ‖Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.

出版信息

J Clin Neurophysiol. 2017 Jul;34(4):300-306. doi: 10.1097/WNP.0000000000000377.

DOI:10.1097/WNP.0000000000000377
PMID:28644199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6032992/
Abstract

The insular cortex, or "Island of Reil," is hidden deep within the lateral sulcus of the brain. Subdivisions within the insula have been identified on the basis of cytoarchitectonics, sulcal landmarks, and connectivity. Depending on the parcellation technique used, the insula can be divided into anywhere between 2 and 13 distinct subdivisions. The insula subserves a wide variety of functions in humans ranging from sensory and affective processing to high-level cognition. Here, we provide a concise summary of known structural and functional features of the human insular cortex with a focus on lesion case studies and recent neuroimaging evidence for considerable functional heterogeneity of this brain region.

摘要

脑岛,即“赖尔岛”,深藏于大脑外侧沟内。脑岛内部的分区已根据细胞构筑学、脑沟标志和连接性得以确定。根据所采用的脑区划分技术,脑岛可被分为2至13个不同的分区。脑岛在人类中发挥着广泛的功能,从感觉和情感处理到高级认知。在此,我们简要总结人类脑岛皮质已知的结构和功能特征,重点关注病变案例研究以及近期有关该脑区功能存在显著异质性的神经影像学证据。

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Soc Cogn Affect Neurosci. 2017 Jan 1;12(1):128-137. doi: 10.1093/scan/nsw152.
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A multi-modal parcellation of human cerebral cortex.人类大脑皮层的多模态分区
Nature. 2016 Aug 11;536(7615):171-178. doi: 10.1038/nature18933. Epub 2016 Jul 20.
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Loss aversion is associated with bilateral insula volume. A voxel based morphometry study.损失厌恶与双侧脑岛体积相关。一项基于体素的形态测量学研究。
在患有抑郁和焦虑的青少年中,皮质厚度与内化症状变化之间的前瞻性关系受慢性应激暴露的调节。
Clin Psychol Sci. 2025 Jul 27. doi: 10.1177/21677026251351850.
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Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.有无快感缺失的重度抑郁症患者脑结构年龄差距估计的改变:一项基于机器学习的研究
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Emotional Processing After Severe Traumatic Brain Injury: Insights from Functional MRI and Pupillometry.重度创伤性脑损伤后的情绪加工:来自功能磁共振成像和瞳孔测量法的见解
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