Huang Yuhao, Kakusa Bina W, Feng Austin, Gattas Sandra, Shivacharan Rajat S, Lee Eric B, Parker Jonathon J, Kuijper Fiene M, Barbosa Daniel A N, Keller Corey J, Bohon Cara, Mikhail Abanoub, Halpern Casey H
Department of Neurosurgery, Stanford University, Stanford, CA, USA.
Departments of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Nat Commun. 2021 Jun 14;12(1):3609. doi: 10.1038/s41467-021-23885-4.
The insulo-opercular network functions critically not only in encoding taste, but also in guiding behavior based on anticipated food availability. However, there remains no direct measurement of insulo-opercular activity when humans anticipate taste. Here, we collect direct, intracranial recordings during a food task that elicits anticipatory and consummatory taste responses, and during ad libitum consumption of meals. While cue-specific high-frequency broadband (70-170 Hz) activity predominant in the left posterior insula is selective for taste-neutral cues, sparse cue-specific regions in the anterior insula are selective for palatable cues. Latency analysis reveals this insular activity is preceded by non-discriminatory activity in the frontal operculum. During ad libitum meal consumption, time-locked high-frequency broadband activity at the time of food intake discriminates food types and is associated with cue-specific activity during the task. These findings reveal spatiotemporally-specific activity in the human insulo-opercular cortex that underlies anticipatory evaluation of food across both controlled and naturalistic settings.
岛盖网络不仅在味觉编码中起关键作用，还在基于预期食物可得性指导行为方面发挥重要作用。然而，目前尚无对人类预期味觉时岛盖活动的直接测量。在此，我们在一项引发预期性和 consummatory 味觉反应的食物任务期间以及随意用餐期间收集直接的颅内记录。虽然左侧后岛叶中占主导的线索特异性高频宽带（70 - 170 Hz）活动对味觉中性线索具有选择性，但前岛叶中稀疏的线索特异性区域对美味线索具有选择性。潜伏期分析表明，这种岛叶活动之前在额盖有非辨别性活动。在随意用餐期间，进食时锁时的高频宽带活动能区分食物类型，并与任务期间的线索特异性活动相关。这些发现揭示了人类岛盖皮质中时空特异性活动，它是在受控和自然环境中对食物进行预期评估的基础。
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