El-Kholy H, Kemppainen B, Ravis W, Hoerr F
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
J Vet Pharmacol Ther. 2006 Feb;29(1):49-53. doi: 10.1111/j.1365-2885.2006.00710.x.
The pharmacokinetics of levamisole was studied in 20 broiler breeder chickens (chickens that give eggs to breed broilers). A single dose of levamisole (40 mg/kg) was administered orally or intravenously to chickens before the onset of egg production, prelay (age = 22 weeks), and repeated at the peak of egg production (age = 32 weeks). A high-pressure liquid chromatographic with ultraviolet detection method (HPLC-UV) was used for quantification of levamisole in plasma. Using compartmental analysis, levamisole followed a three-compartmental open model with mean values of alpha = 0.1224 and 0.4968, beta = 0.01663 and 0.01813, gamma = 0.002 and 0.002/min at the prelay and at the peak of egg production periods, respectively. The mean values for volume of distribution at steady state (V(ss)), determined by compartmental analysis, were significantly different for prelay and peak of egg production (8.358 and 13.581 mL/kg), respectively.
在20只肉种鸡（用于繁育肉雏鸡的母鸡）中研究了左旋咪唑的药代动力学。在产蛋前（22周龄），对鸡口服或静脉注射单剂量左旋咪唑（40mg/kg），并在产蛋高峰期（32周龄）重复给药。采用高压液相色谱-紫外检测法（HPLC-UV）对血浆中的左旋咪唑进行定量。通过房室分析，左旋咪唑在产蛋前和产蛋高峰期分别遵循三室开放模型，α平均值分别为0.1224和0.4968，β平均值分别为0.01663和0.01813，γ平均值分别为0.002和0.002/min。通过房室分析确定的稳态分布容积（V(ss)）平均值在产蛋前和产蛋高峰期有显著差异，分别为8.358和13.581mL/kg。
