Schmidt S, Wagner U, Oehr P, Krebs D
Universitäts-Frauenklinik, Universität Bonn.
Zentralbl Gynakol. 1992;114(6):307-11.
The clinical report addresses the first application of a antibody-targeted photodynamic laser therapy with Phthalocyanines. Photodynamic therapy (PDT) has been proposed as a further treatment modality in oncology. The concept of PDT is based on the interaction between a dye which is accumulated in the target and laserlight. The phototoxic effect is achieved by the augmentation of oxygen radicals. The improvement of the selectivity and the reduction of side-effects is achieved by our concept of using an antibody-targeted phthalocyane induced PDT. The clinical application of the antibody-targeted Phthalocyanine was performed in 3 patients suffering from an advanced ovarian carcinoma (FIGO III). By means of an ultramicroscopical analysis a selective devitalisation of tumor cells was demonstrated. The perspective of PDT reaches far beyond the application for the ovarian carcinomas and relates to all tumor types, where the presence of tumor-associated antigens implicates a treatment in a similar way.
该临床报告阐述了酞菁类抗体靶向光动力激光疗法的首次应用。光动力疗法（PDT）已被提议作为肿瘤学中的一种进一步治疗方式。PDT的概念基于积聚在靶标的染料与激光之间的相互作用。通过增加氧自由基来实现光毒性效应。我们使用抗体靶向酞菁诱导PDT的概念实现了选择性的提高和副作用的减少。抗体靶向酞菁在3例晚期卵巢癌（国际妇产科联盟III期）患者中进行了临床应用。通过超显微分析证明了肿瘤细胞的选择性失活。PDT的前景远远超出了卵巢癌的应用范围，涉及所有肿瘤类型，在这些肿瘤类型中，肿瘤相关抗原的存在意味着可以以类似的方式进行治疗。
