膜蛋白结构基因组学的最新进展。
Recent developments in membrane-protein structural genomics.
作者信息
Gao Fei Philip, Cross Timothy A
机构信息
Department of Chemistry and Biochemistry, and the National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA.
出版信息
Genome Biol. 2005;6(13):244. doi: 10.1186/gb-2005-6-13-244. Epub 2006 Jan 3.
Abstract
Recent work has identified the topology of almost all the inner membrane proteins in Escherichia coli, and advances in nuclear magnetic resonance spectroscopy now allow the determination of alpha-helical membrane protein structures at high resolution. Together these developments will help overcome the current limitations of high-throughput determination of membrane protein structures.
摘要
最近的研究已经确定了大肠杆菌中几乎所有内膜蛋白的拓扑结构，并且核磁共振光谱技术的进展现在使得能够高分辨率地测定α-螺旋膜蛋白的结构。这些进展共同将有助于克服目前膜蛋白结构高通量测定的局限性。
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