Foxman Betsy, Gillespie Brenda, Manning Shannon D, Howard Laura J, Tallman Patricia, Zhang Lixin, Marrs Carl F
Department of Epidemiology, University of Michigan School of Public Health, 109 South Observatory Street, Ann Arbor, MI 48109, USA.
Am J Epidemiol. 2006 Mar 15;163(6):544-51. doi: 10.1093/aje/kwj075. Epub 2006 Jan 18.
Group B Streptococcus causes a variety of morbid and sometimes fatal conditions affecting individuals of all age groups. There are nine known serotypes of this Gram-positive coccus but few estimates of the incidence and duration of its colonization and none by serotype in the literature. In 2001, the authors conducted a prospective cohort study among 257 men and women living in a single dormitory in Ann Arbor, Michigan. The 3-week incidence with any serotype was 11.3% (+/-3.9%) among women and 8.8% (+/-3.0%) among men; 3-week incidence rates were highest for serotype V (4.7% for women and 3.5% for men) and type Ia (2.3% for women and 2.4% for men), with no significant differences by gender. The estimated average duration of any group B Streptococcus colonization was longer for women (13.7 weeks) than men (8.5 weeks); serotype Ia was carried an average of 6.5 weeks longer in women, and serotype III was carried 4.9 weeks longer. Colonization with more than one serotype occurred significantly less than would be expected by chance (p <<< 0.001). Based on the overall incidence, transmission occurred between roommate pairs at the rate expected. Group B Streptococcus colonization is frequent and dynamic, but it is not transmitted by casual contact.
B族链球菌可引发多种疾病,有时甚至会导致各年龄组个体死亡。这种革兰氏阳性球菌共有九种已知血清型,但关于其定植的发生率和持续时间的估计很少,且文献中没有按血清型进行的相关估计。2001年,作者在密歇根州安阿伯市一个宿舍居住的257名男女中开展了一项前瞻性队列研究。女性中任何血清型的3周发生率为11.3%(±3.9%),男性为8.8%(±3.0%);血清型V的3周发生率最高(女性为4.7%,男性为3.5%),Ia型次之(女性为2.3%,男性为2.4%),两性之间无显著差异。估计女性B族链球菌任何血清型的平均定植持续时间(13.7周)长于男性(8.5周);Ia型在女性中的平均携带时间长6.5周,III型长4.9周。多种血清型的定植发生率显著低于随机预期(p <<< 0.001)。基于总体发生率,室友之间的传播以预期速率发生。B族链球菌定植很常见且具有动态性,但不会通过日常接触传播。