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TrwB：一种参与细菌接合过程中DNA转运的F(1)-ATP酶样分子马达。

TrwB: an F(1)-ATPase-like molecular motor involved in DNA transport during bacterial conjugation.

作者信息

Cabezon Elena, de la Cruz Fernando

机构信息

Departamento de Biología Molecular (Unidad Asociada al CIB-CSIC), Universidad de Cantabria, C. Herrera Oria s/n, 39011 Santander, Spain.

出版信息

Res Microbiol. 2006 May;157(4):299-305. doi: 10.1016/j.resmic.2005.12.002. Epub 2005 Dec 29.

DOI:10.1016/j.resmic.2005.12.002
PMID:16427770
Abstract

The mechanism by which TrwB acts as a DNA transporter in bacterial conjugation is analyzed. Based on a parallelism between TrwB and F(1)-ATPase, TrwB would use the energy derived from ATP hydrolysis to pump DNA through its central channel, in a manner similar to that used by F(1)-ATPase to produce a rotary movement of the central gamma-subunit.

摘要

分析了TrwB在细菌接合中作为DNA转运蛋白的作用机制。基于TrwB与F₁-ATP酶之间的相似性，TrwB会利用ATP水解产生的能量通过其中心通道泵送DNA，其方式类似于F₁-ATP酶使中心γ亚基产生旋转运动的方式。

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