Chandola Tarani, Brunner Eric, Marmot Michael
Department of Epidemiology and Public Health, University College London, London WC1E 6BT.
BMJ. 2006 Mar 4;332(7540):521-5. doi: 10.1136/bmj.38693.435301.80. Epub 2006 Jan 20.
To investigate the association between stress at work and the metabolic syndrome. [table: see text].
Prospective cohort study investigating the association between work stress and the metabolic syndrome.
10 308 men and women, aged 35-55, employed in 20 London civil service departments at baseline (the Whitehall II study); follow-up was an average of 14 years.
Work stress based on the iso-strain model, measured on four occasions (1985-99). Biological measures of the metabolic syndrome, based on the National Cholesterol Education Program definition, measured in 1997-9.
A dose-response relation was found between exposure to work stressors over 14 years and risk of the metabolic syndrome, independent of other relevant risk factors. Employees with chronic work stress (three or more exposures) were more than twice as likely to have the syndrome than those without work stress (odds ratio adjusted for age and employment grade 2.25, 95% confidence interval 1.31 to 3.85).
Stress at work is an important risk factor for the metabolic syndrome. The study provides evidence for the biological plausibility of the link between psychosocial stressors from everyday life and heart disease.
研究工作压力与代谢综合征之间的关联。[表格：见正文]。
前瞻性队列研究，调查工作压力与代谢综合征之间的关联。
10308名年龄在35 - 55岁之间的男性和女性，基线时受雇于伦敦20个公务员部门（白厅II研究）；随访平均为14年。
基于等应变模型的工作压力，在四个时间段（1985 - 1999年）进行测量。基于美国国家胆固醇教育计划定义的代谢综合征生物学指标，在1997 - 1999年进行测量。
在14年期间，工作压力源暴露与代谢综合征风险之间存在剂量反应关系，且独立于其他相关风险因素。患有慢性工作压力（三次或更多次暴露）的员工患该综合征的可能性是无工作压力员工的两倍多（年龄和就业等级调整后的优势比为2.25，95%置信区间为1.31至3.85）。
工作压力是代谢综合征的一个重要风险因素。该研究为日常生活中的心理社会压力源与心脏病之间联系的生物学合理性提供了证据。
