Cammu Guy, De Witte Jan, De Veylder Jan, Byttebier Geert, Vandeput Dirk, Foubert Luc, Vandenbroucke Geert, Deloof Thierry
Department of Anesthesiology and Critical Care Medicine, OLV Clinic, Aalst, Belgium.
Anesth Analg. 2006 Feb;102(2):426-9. doi: 10.1213/01.ane.0000195543.61123.1f.
Postoperative residual paralysis is an important complication of the use of neuromuscular blocking drugs. In this prospective study, the incidence of residual paralysis detected as a train-of-four response <90% was less frequent in surgical outpatients (38%) than inpatients (47%) (P = 0.001). This might have been the result of the more frequent use of mivacurium for outpatients. Before undertaking tracheal extubation, the anesthesiologists had applied clinical criteria (outpatients, 49%; inpatients, 45%), pharmacological reversal (26%, 25%), neuromuscular transmission monitoring (12%, 11%), or a combination of these. None of these measures seemed to reduce the incidence of residual paralysis except for quantitative train-of-four monitoring. Postoperatively, eight individual clinical tests or a sum of these tests were also unable to predict residual paralysis by train-of-four. Although the incidence of residual paralysis was less frequent in surgical outpatients, predictive criteria were not evident.
术后残余麻痹是使用神经肌肉阻滞剂的一种重要并发症。在这项前瞻性研究中,以四个成串刺激反应<90%检测到的残余麻痹发生率在外科门诊患者(38%)中比住院患者(47%)更低(P = 0.001)。这可能是门诊患者更频繁使用米库氯铵的结果。在进行气管拔管前,麻醉医生采用了临床标准(门诊患者为49%;住院患者为45%)、药物逆转(26%,25%)、神经肌肉传递监测(12%,11%)或这些方法的联合应用。除了定量四个成串刺激监测外,这些措施似乎都不能降低残余麻痹的发生率。术后,八项单独的临床检查或这些检查的总和也无法通过四个成串刺激预测残余麻痹。尽管外科门诊患者中残余麻痹的发生率较低,但预测标准并不明确。