Canning Brendan J
Chest. 2006 Jan;129(1 Suppl):33S-47S. doi: 10.1378/chest.129.1_suppl.33S.
To describe the anatomy and neurophysiology of the cough reflex.
A review of the literature was carried out using PubMed and the ISI Web of Knowledge from 1951 to 2004. Most of the referenced studies were carried out in animals
Studies carried out in animals provide suggestive but inconclusive evidence that C-fibers and rapidly adapting receptors (RARs) arising from the vagus nerves mediate coughing. Recent studies also have suggested that a vagal afferent nerve subtype that is not readily classified as a RAR or a C-fiber may play an important role in regulating cough. Afferent nerves innervating other viscera, as well as somatosensory nerves innervating the chest wall, diaphragm, and abdominal musculature also likely play a less essential but important accessory role in regulating cough. The responsiveness and morphology of the airway vagal afferent nerve subtypes and the extrapulmonary afferent nerves that regulate coughing are described.
描述咳嗽反射的解剖结构和神经生理学。
利用1951年至2004年的PubMed和ISI知识网络对文献进行综述。大多数引用的研究是在动物身上进行的。
在动物身上进行的研究提供了提示性但不确定的证据，表明来自迷走神经的C纤维和快速适应性受体（RARs）介导咳嗽。最近的研究还表明，一种不易归类为RAR或C纤维的迷走传入神经亚型可能在调节咳嗽中起重要作用。支配其他内脏的传入神经以及支配胸壁、膈肌和腹部肌肉组织的躯体感觉神经在调节咳嗽中也可能起次要但重要的辅助作用。描述了调节咳嗽的气道迷走传入神经亚型和肺外传入神经的反应性和形态。
