Lundby C, Damsgaard R
The Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Carsten@CM RC.dk
Scand J Med Sci Sports. 2006 Feb;16(1):35-40. doi: 10.1111/j.1600-0838.2004.00434.x.
Maximal aerobic power at high altitude (<4000 m) does not increase with altitude acclimatization. In order to investigate the isolated effects of increased arterial oxygen content (CaO2) on maximal oxygen uptake (VO2max) in hypoxia, we studied 10 subjects during exercise in acute exposure to 12.6% O2 before and after novel erythropoiesis stimulating protein (NESP) induced increases in CaO2. Over a period of 1 month, weekly NESP treatment increased resting hemoglobin (Hb) from 13.8+/-0.9 to 16.2+/-0.5 g/dL, hematocrit from 42.1+/-0.6% to 49.0+/-1.5%, and CaO2 from 189.7+/-3.0 to 218.6+/-5.7 mL/L. At maximal exercise CaO2 was increased from 172.3+/-3.7 to 191.5+/-3.8 mL/L with NESP treatment, and although maximal heart rate was similar in both conditions (178.4+/-2.6 and 180.9+/-2.5 b.p.m.) VO2max remained unaltered, the values being 3.12+/-2.0 and 3.12+/-2.0, before and after NESP treatment, respectively. NESP-injections in human subjects causes Hb and accordingly CaO2 to increase both in normoxia and hypoxia. Despite increases in CaO2 at maximal exercise in hypoxia VO2max is not increased.
高海拔（<4000米）时的最大有氧能力不会随着高原适应而增加。为了研究动脉血氧含量（CaO2）增加对低氧环境下最大摄氧量（VO2max）的单独影响，我们对10名受试者在急性暴露于12.6%氧气环境下运动时进行了研究，分别在新型促红细胞生成刺激蛋白（NESP）诱导CaO2增加前后进行。在1个月的时间里，每周进行NESP治疗使静息血红蛋白（Hb）从13.8±0.9克/分升增加到16.2±0.5克/分升，血细胞比容从42.1±0.6%增加到49.0±1.5%，CaO2从189.7±3.0毫升/升增加到218.6±5.7毫升/升。在最大运动时，NESP治疗使CaO2从172.3±3.7毫升/升增加到191.5±3.8毫升/升，尽管两种情况下的最大心率相似（分别为178.4±2.6和180.9±2.5次/分钟），但VO2max保持不变，NESP治疗前后的值分别为3.12±2.0和3.12±2.0。对人类受试者注射NESP会使常氧和低氧状态下的Hb以及相应的CaO2均增加。尽管在低氧环境下最大运动时CaO2增加，但VO2max并未增加。
