Sheikh Khalid A, Baie Saringat H J, Khan Gul Majeed
School of Pharmacy, International Medical University, 57000, Kuala Lumpur, Malaysia.
Pak J Pharm Sci. 2005 Jan;18(1):1-5.
Topical emulsions stabilized with non-ionic emulsifiers have been an attractive alternative as vehicles for drug delivery, particularly for the patients suffering from dermatological problems. Haruan (a natural wound healer) creams were formulated with different types of emulsifiers (Tween 80 and Span 80) using different grades of Malaysian Palm-oleins (DFPL 56, 60, 62 and 65). The stability (at room temperature and accelerated stability testing) of the various creams was evaluated at different temperatures (5, 25 and 45 degrees C) for a period of 6 months by measuring changes in droplet size, viscosity and percentage oil separation. The emulsifier type and concentration showed pronounced effect on the physicochemical properties of the cream, whereas storage time did not. This study suggested that the choice of emulsifiers and concentration of haruan extract are the most important factors in the stability of the haruan creams.
用非离子乳化剂稳定的外用乳剂作为药物递送载体已成为一种有吸引力的选择，特别是对于患有皮肤病问题的患者。使用不同等级的马来西亚棕榈油精（DFPL 56、60、62和65），用不同类型的乳化剂（吐温80和司盘80）配制了哈鲁安（一种天然伤口愈合剂）乳膏。通过测量液滴大小、粘度和油相分离百分比的变化，在不同温度（5、25和45摄氏度）下对各种乳膏的稳定性（在室温下和加速稳定性试验）进行了6个月的评估。乳化剂类型和浓度对乳膏的物理化学性质有显著影响，而储存时间则没有。这项研究表明，乳化剂的选择和哈鲁安提取物的浓度是哈鲁安乳膏稳定性的最重要因素。
