HuR是一种RNA结合蛋白，参与细胞分化的调控。
HuR, an RNA-binding protein, involved in the control of cellular differentiation.
作者信息
Cherry Joy, Karschner Vesna, Jones Heath, Pekala Phillip H
机构信息
Department of Biochemistry and Molecular Biology, The Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
出版信息
In Vivo. 2006 Jan-Feb;20(1):17-23.
HuR is an RNA-binding protein that resides predominantly in the nucleus but shuttles to the cytosol carrying mRNAs containing a uridylate-rich region in the 3'untranslated region. Data suggest that HuR is involved in the control of the differentiation process through a tightly regulated selection of mRNAs to be shuttled to the cytosol for translation. In this review, the function of HuR in the differentiation process of preadipocytes is examined in the context of specific mRNAs selected by HuR for translocation to the cytosol.
HuR是一种RNA结合蛋白，主要存在于细胞核中，但会穿梭至细胞质，携带3'非翻译区含有富含尿苷酸区域的mRNA。数据表明，HuR通过严格调控对要穿梭至细胞质进行翻译的mRNA的选择，参与分化过程的控制。在这篇综述中，我们结合HuR选择转运至细胞质的特定mRNA，探讨了HuR在前脂肪细胞分化过程中的作用。
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