Ishay A, Lavi I, Luboshitzky R
Institute of Endocrinology, Haemek Medical Center, Afula, Israel.
Diabet Med. 2006 Feb;23(2):185-8. doi: 10.1111/j.1464-5491.2005.01758.x.
Asymptomatic bacteriuria (ASB) has been considered as a complication in diabetic women. The reported data on the prevalence and various risk factors for ASB appear to be conflicting. Consequently, we investigated the prevalence and major risk factors of ASB in women with Type 2 diabetes mellitus.
A total of 411 non-pregnant women (aged 59.6 +/- 10.8 years) with Type 2 diabetes, and 160 women without diabetes (aged 53.3 +/- 15.1 years) assigned as controls, attending an outpatient endocrine clinic in a university-affiliated teaching hospital, were included. All participating women were interviewed and screened for the presence of ASB. In all participants, fasting blood glucose, HbA(1c) and renal function were measured. Complications of diabetes were also assessed.
Of the 411 diabetic women, 25 (6.1%) had ASB, compared with four of 160 (2.5%) in control women (P = 0.07). Independent risk factors for the presence of ASB were albuminuria > 150 mg/24 h [odds ratio (OR) 4.96 (95% CI 1.64-15.0, P = 0.005)] and serum creatinine [OR 3.5 (95% CI 1.4-8.8, P = 0.008)]. No significant association was evident with age, BMI, duration of disease, glycaemic control assessed by HbA(1c) or chronic complications of diabetes, namely macrovascular disease, neuropathy and retinopathy.
Women with Type 2 diabetes are not at higher risk of developing ASB than non-diabetic women. Independent and significant risk factors for ASB are macroalbuminuria and serum creatinine. The low prevalence of ASB found in this study may be as a result of the ethnic origin of these women and the circumcised state of their partners.
无症状菌尿（ASB）被视为糖尿病女性的一种并发症。关于ASB患病率及各种危险因素的报道数据似乎相互矛盾。因此，我们调查了2型糖尿病女性中ASB的患病率及主要危险因素。
纳入了在一所大学附属医院门诊内分泌科就诊的411名非妊娠2型糖尿病女性（年龄59.6±10.8岁）以及160名非糖尿病女性（年龄53.3±15.1岁）作为对照。所有参与的女性均接受访谈并筛查是否存在ASB。对所有参与者测量空腹血糖、糖化血红蛋白（HbA1c）和肾功能。还评估了糖尿病并发症。
411名糖尿病女性中，25名（6.1%）患有ASB，而160名对照女性中有4名（2.5%）患有ASB（P = 0.07）。ASB存在的独立危险因素为蛋白尿>150mg/24小时[比值比（OR）4.96（95%可信区间1.64 - 15.0，P = 0.005）]和血清肌酐[OR 3.5（95%可信区间1.4 - 8.8，P = 0.008）]。与年龄、体重指数、病程、通过糖化血红蛋白评估的血糖控制或糖尿病慢性并发症（即大血管疾病神经病变和视网膜病变）无明显显著关联。
2型糖尿病女性发生ASB的风险并不高于非糖尿病女性。ASB的独立且显著的危险因素是大量蛋白尿和血清肌酐。本研究中发现的ASB低患病率可能是由于这些女性的种族起源及其伴侣的包皮环切状态。
