Komiya Hideaki, Mori Yutaka, Yokose Takuo, Tajima Naoko
Department of Exercise Physiology, Utsunomiya University, Japan.
Tohoku J Exp Med. 2006 Feb;208(2):123-32. doi: 10.1620/tjem.208.123.
Epidemiological and clinical studies on the lifestyle-related obesity have identified smoking, physical activity and alcohol intake as risk factors for obesity. However, no consensus has yet been reached on the effect of smoking on visceral adiposity. This study was designed to assess whether smoking is associated with the accumulation of visceral fat, glucose and lipid metabolism. The subjects were 450 males aged from 24 to 68 years old, who were examined at the health control center in the regular health check conducted by their company. A self-administered questionnaire was used to ascertain smoking status, daily physical activity and alcohol drinking. The number of Brinkman index as an index for smoking status was positively related to being visceral fat area (VFA). In smokers whose Brinkman index was higher, the percent of subjects with abnormal body mass index, VFA, triglyceride, high density lipoprotein-cholesterol, atherosclerotic index, plasma glucose, immunoreactive insulin, or homeostasis model assessment of insulin resistance (HOMA-IR) was higher than that in non-smokers. When evaluated in terms of age-adjusted odds ratios for incidence of a VFA of 100 cm(2) or greater, alcohol drinking was associated with the highest odds ratio. Smoking, physical inactivity and excessive alcohol drinking were associated with visceral adiposity, and smoking affected glucose and lipid metabolism. In conclusions, these findings suggest that smoking is a risk factor for visceral fat accumulation and deterioration of glucose and lipid metabolism.
关于生活方式相关肥胖的流行病学和临床研究已将吸烟、体育活动和酒精摄入确定为肥胖的危险因素。然而，对于吸烟对内脏脂肪过多的影响尚未达成共识。本研究旨在评估吸烟是否与内脏脂肪堆积、葡萄糖和脂质代谢有关。研究对象为450名年龄在24至68岁之间的男性，他们在公司定期健康检查时于健康控制中心接受了检查。采用自行填写的问卷来确定吸烟状况、日常体育活动和饮酒情况。作为吸烟状况指标的布林克曼指数与内脏脂肪面积（VFA）呈正相关。在布林克曼指数较高的吸烟者中，体重指数、VFA、甘油三酯、高密度脂蛋白胆固醇、动脉粥样硬化指数、血糖、免疫反应性胰岛素或胰岛素抵抗稳态模型评估（HOMA-IR）异常的受试者百分比高于非吸烟者。当以年龄调整后的优势比评估VFA为100平方厘米或更大的发生率时，饮酒的优势比最高。吸烟、缺乏体育活动和过量饮酒与内脏脂肪过多有关，且吸烟会影响葡萄糖和脂质代谢。总之，这些发现表明吸烟是内脏脂肪堆积以及葡萄糖和脂质代谢恶化的危险因素。
