Bediz Cem Seref, Baltaci Abdulkerim Kasim, Mogulkoc Rasim, Oztekin Esma
Department of Physiology, Dokuz Eylul University Medical School, Izmir, Turkey.
Tohoku J Exp Med. 2006 Feb;208(2):133-40. doi: 10.1620/tjem.208.133.
Extremely low-frequency (0-300 Hz) electromagnetic fields (EMFs) generated by power lines, wiring and home appliances are ubiquitous in our environment. All populations are now exposed to EMF, and exposure to EMF may pose health risks. Some of the adverse health effects of EMF exposure are lipid peroxidation and cell damage in various tissues. This study has investigated the effects of EMF exposure and zinc administration on lipid peroxidation in the rat brain. Twenty-four male Sprague-Dawley rats were randomly allocated to three groups; they were maintained untreated for 6 months (control, n = 8), exposed to low-frequency (50 Hz) EMF for 5 minutes every other day for 6 months (n = 8), or exposed to EMF and received zinc sulfate daily (3 mg/kg/day) intraperitoneally (n = 8). We measured plasma levels of zinc and thiobarbituric acid reactive substances (TBARS), and levels of reduced glutathione (GSH) in erythrocytes. TBARS and GSH levels were also determined in the brain tissues. TBARS levels in the plasma and brain tissues were higher in EMF-exposed rats with or without zinc supplementation, than those in controls (p < 0.001). In addition, TBARS levels were significantly lower in the zinc-supplemented rats than those in the EMF-exposed rats (p < 0.001). GSH levels were significantly decreased in the brain and erythrocytes of the EMF-exposed rats (p < 0.01), and were highest in the zinc-supplemented rats (p < 0.001). Plasma zinc was significantly lower in the EMF-exposed rats than those in controls (p < 0.001), while it was highest in the zinc-supplemented rats (p < 0.001). The present study suggests that long-term exposure to low-frequency EMF increases lipid peroxidation in the brain, which may be ameliorated by zinc supplementation.
输电线、布线及家用电器产生的极低频（0 - 300赫兹）电磁场在我们的环境中无处不在。现在所有人群都暴露于电磁场中，而暴露于电磁场可能会带来健康风险。电磁场暴露的一些不良健康影响包括各种组织中的脂质过氧化和细胞损伤。本研究调查了电磁场暴露和补锌对大鼠大脑脂质过氧化的影响。将24只雄性斯普拉格 - 道利大鼠随机分为三组；让它们在6个月内不接受任何处理（对照组，n = 8），每隔一天暴露于低频（50赫兹）电磁场5分钟，持续6个月（n = 8），或者暴露于电磁场并每天腹腔注射硫酸锌（3毫克/千克/天）（n = 8）。我们测量了血浆锌水平、硫代巴比妥酸反应性物质（TBARS）以及红细胞中还原型谷胱甘肽（GSH）的水平。还测定了脑组织中的TBARS和GSH水平。无论是否补充锌，暴露于电磁场的大鼠血浆和脑组织中的TBARS水平均高于对照组（p < 0.001）。此外，补锌大鼠的TBARS水平显著低于暴露于电磁场的大鼠（p < 0.001）。暴露于电磁场的大鼠大脑和红细胞中的GSH水平显著降低（p < 0.01），而在补锌大鼠中最高（p < 0.001）。暴露于电磁场的大鼠血浆锌水平显著低于对照组（p < 0.001），而在补锌大鼠中最高（p < 0.001）。本研究表明，长期暴露于低频电磁场会增加大脑中的脂质过氧化，而补锌可能会改善这种情况。
