Cathers Justin W, Wilson Carolyn F G, Webb Michael D, Alvarez Marta E D, Schiffman Teresa, Taylor Samuel
Department of Pediatric Dentistry, Baylor College of Dentistry, Dallas, TX, USA.
Pediatr Dent. 2005 Sep-Oct;27(5):395-400.
The purpose of this study was to compare the safety and efficacy of submucosal-administered meperidine (SM) and oral-administered meperidine (OM). Both regimens were used in conjunction with oral hydroxyzine for the sedation of children for dental treatment.
Twenty preschool-age children, with previous histories of uncooperative behavior, were randomly assigned to first receive a sedation regimen of either SM (0.5 mg/ lb), or OM (1 mg/lb), both with oral hydroxyzine (0.5 mg/lb). A cross-over design was utilized so that each child received both regimens. Safety was monitored through vital signs and side effects. Efficacy was measured with Houpt and Frankl behavior ratings.
Vital signs remained stable during both treatments. Differences noted were clinically insignificant. The major side effects reported during submucosal injection included pain (58%) and edema (26%). All blinded behavior ratings, in both sedation regimens, significantly improved from presedation Frankl ratings. No significant differences existed between treatments. Success was 63% in the SM group and 80% in the OM group. The percentages were not statistically significant (P=.219).
Both methods of administration were found to be safe and effective for sedating uncooperative pediatric dental patients. Neither was significantly more effective or safer than the other.
本研究旨在比较黏膜下注射哌替啶（SM）和口服哌替啶（OM）的安全性和有效性。两种给药方案均与口服羟嗪联合使用，用于儿童牙科治疗的镇静。
20名有不合作行为既往史的学龄前儿童被随机分配，先接受SM（0.5mg/磅）或OM（1mg/磅）的镇静方案，两者均联合口服羟嗪（0.5mg/磅）。采用交叉设计，使每个儿童接受两种方案。通过生命体征和副作用监测安全性。用豪普特和弗兰克尔行为评分衡量有效性。
两种治疗期间生命体征均保持稳定。观察到的差异在临床上无显著意义。黏膜下注射期间报告的主要副作用包括疼痛（58%）和水肿（26%）。在两种镇静方案中，所有盲法行为评分均较镇静前弗兰克尔评分有显著改善。治疗之间无显著差异。SM组成功率为63%，OM组为80%。这些百分比无统计学意义（P = 0.219）。
发现两种给药方法对不合作的儿科牙科患者镇静均安全有效。两者在有效性或安全性方面均无显著差异。
