强力霉素减轻了博来霉素诱导的小鼠肺纤维化。
Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice.
作者信息
Fujita Masaki, Ye Qing, Ouchi Hiroshi, Harada Eiji, Inoshima Ichiro, Kuwano Kazuyoshi, Nakanishi Yoichi
机构信息
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812, Japan.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):739-43. doi: 10.1128/AAC.50.2.739-743.2006.
Abstract
The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
摘要
在小鼠中，博来霉素给药前给予强力霉素可减轻肺纤维化。强力霉素可减轻支气管肺泡中性粒细胞浸润和明胶酶活性，但酪蛋白溶解活性不受影响。已形成的纤维化不受强力霉素影响。因此，强力霉素可能通过抗菌活性以外的生物学活性来减缓肺纤维化。
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