喹诺酮类药物对小鼠流感病毒感染后继发性肺炎链球菌肺炎的疗效。
Efficacy of quinolones against secondary pneumococcal pneumonia after influenza virus infection in mice.
作者信息
Hayashi Katsuhiko, Kadowaki Shin-etsu, Takei Masaya, Fukuda Hideyuki
机构信息
Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Shimotsuga, Tochigi 329-0114, Japan.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):748-51. doi: 10.1128/AAC.50.2.748-751.2006.
Abstract
We established a mouse model of secondary pneumococcal pneumonia after influenza virus infection and investigated the efficacy of several quinolones against pneumonia in this model. Gatifloxacin exhibited the highest efficacy among the quinolones examined and is probably useful for the treatment of secondary bacterial pneumonia.
摘要
我们建立了流感病毒感染后继发性肺炎球菌肺炎的小鼠模型，并在此模型中研究了几种喹诺酮类药物对肺炎的疗效。加替沙星在所检测的喹诺酮类药物中疗效最高，可能对继发性细菌性肺炎的治疗有用。
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