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Influenza-associated hospitalizations in the United States.美国与流感相关的住院情况。
JAMA. 2004 Sep 15;292(11):1333-40. doi: 10.1001/jama.292.11.1333.
2
Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza.抗病毒治疗对流感后继发性细菌性肺炎结局的影响。
J Infect Dis. 2004 Aug 1;190(3):519-26. doi: 10.1086/421525. Epub 2004 Jun 30.
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IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection.白细胞介素-10是流感感染后对肺炎球菌肺炎易感性增强的重要介质。
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Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae.神经氨酸酶在流感病毒与肺炎链球菌致死性协同作用中的作用
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Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice.甲型流感病毒感染的宿主会增强小鼠侵袭性化脓性链球菌感染。
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Mortality associated with influenza and respiratory syncytial virus in the United States.美国与流感和呼吸道合胞病毒相关的死亡率。
JAMA. 2003 Jan 8;289(2):179-86. doi: 10.1001/jama.289.2.179.
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Gatifloxacin used for therapy of outpatient community-acquired pneumonia caused by Streptococcus pneumoniae.加替沙星用于治疗由肺炎链球菌引起的门诊社区获得性肺炎。
Diagn Microbiol Infect Dis. 2002 Sep;44(1):93-100. doi: 10.1016/s0732-8893(02)00448-0.

喹诺酮类药物对小鼠流感病毒感染后继发性肺炎链球菌肺炎的疗效。

Efficacy of quinolones against secondary pneumococcal pneumonia after influenza virus infection in mice.

作者信息

Hayashi Katsuhiko, Kadowaki Shin-etsu, Takei Masaya, Fukuda Hideyuki

机构信息

Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Shimotsuga, Tochigi 329-0114, Japan.

出版信息

Antimicrob Agents Chemother. 2006 Feb;50(2):748-51. doi: 10.1128/AAC.50.2.748-751.2006.

DOI:10.1128/AAC.50.2.748-751.2006
PMID:16436736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1366889/
Abstract

We established a mouse model of secondary pneumococcal pneumonia after influenza virus infection and investigated the efficacy of several quinolones against pneumonia in this model. Gatifloxacin exhibited the highest efficacy among the quinolones examined and is probably useful for the treatment of secondary bacterial pneumonia.

摘要

我们建立了流感病毒感染后继发性肺炎球菌肺炎的小鼠模型，并在此模型中研究了几种喹诺酮类药物对肺炎的疗效。加替沙星在所检测的喹诺酮类药物中疗效最高，可能对继发性细菌性肺炎的治疗有用。