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本文引用的文献

1
The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity.棉鼠（棉鼠属）是人类偏肺病毒感染、发病机制及保护性免疫的一种适宜的小动物模型。
J Virol. 2005 Sep;79(17):10944-51. doi: 10.1128/JVI.79.17.10944-10951.2005.
2
Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease.社区获得性肺炎和慢性阻塞性肺疾病加重的成人患者中的人偏肺病毒感染
Clin Infect Dis. 2005 Aug 15;41(4):498-502. doi: 10.1086/431981. Epub 2005 Jul 15.
3
Pathogenesis of human metapneumovirus lung infection in BALB/c mice and cotton rats.人偏肺病毒在BALB/c小鼠和棉鼠肺部感染的发病机制
J Virol. 2005 Jul;79(14):8894-903. doi: 10.1128/JVI.79.14.8894-8903.2005.
4
Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccines.建立棉鼠-人偏肺病毒（hMPV）模型以鉴定和评估潜在的hMPV抗病毒药物及疫苗。
Antiviral Res. 2005 Apr;66(1):57-66. doi: 10.1016/j.antiviral.2004.12.009.
5
Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies.尽管存在中和抗体，人偏肺病毒仍可在BALB/c小鼠体内持续存在。
J Virol. 2004 Dec;78(24):14003-11. doi: 10.1128/JVI.78.24.14003-14011.2004.
6
Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design.鉴定用于评估人偏肺病毒（hMPV）候选疫苗的小动物和灵长类动物模型及其对hMPV疫苗设计的意义。
J Gen Virol. 2004 Jun;85(Pt 6):1655-1663. doi: 10.1099/vir.0.79805-0.
7
Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice.呼吸道合胞病毒可诱发小鼠肺炎、细胞因子反应、气道阻塞以及与长期气道高反应性相关的慢性炎性浸润。
J Infect Dis. 2004 May 15;189(10):1856-65. doi: 10.1086/386372. Epub 2004 Apr 29.
8
Human metapneumovirus: a new player among respiratory viruses.人偏肺病毒：呼吸道病毒中的新成员。
Clin Infect Dis. 2004 Apr 1;38(7):983-90. doi: 10.1086/382536. Epub 2004 Mar 15.
9
Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro.利巴韦林和免疫血清球蛋白在体外对人偏肺病毒和呼吸道合胞病毒抑制作用的比较。
Antiviral Res. 2003 Sep;60(1):51-9. doi: 10.1016/s0166-3542(03)00153-0.
10
Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups.与人类偏肺病毒相关的病毒学特征及临床表现：一种可导致各年龄组急性呼吸道感染的新型副粘病毒
J Infect Dis. 2002 Nov 1;186(9):1330-4. doi: 10.1086/344319. Epub 2002 Oct 8.

利巴韦林与糖皮质激素治疗对人偏肺病毒感染小鼠模型的影响。

Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.

作者信息

Hamelin Marie-Eve, Prince Gregory A, Boivin Guy

机构信息

Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec, Sainte-Foy, Québec, Canada.

出版信息

Antimicrob Agents Chemother. 2006 Feb;50(2):774-7. doi: 10.1128/AAC.50.2.774-777.2006.

DOI:10.1128/AAC.50.2.774-777.2006
PMID:16436743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1366914/
Abstract

Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log10) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.

摘要

用利巴韦林（40毫克/千克体重，每天腹腔注射两次）、皮质酮（在水中浓度为0.2毫克/毫升）或两种方式联合处理感染人偏肺病毒（hMPV）的BALB/c小鼠。与对照组相比，利巴韦林在感染后第5天显著降低了肺中hMPV的复制（降低5个对数10）以及整体肺部炎症，而糖皮质激素仅减轻了肺泡和间质炎症。