利巴韦林与糖皮质激素治疗对人偏肺病毒感染小鼠模型的影响。
Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.
作者信息
Hamelin Marie-Eve, Prince Gregory A, Boivin Guy
机构信息
Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec, Sainte-Foy, Québec, Canada.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):774-7. doi: 10.1128/AAC.50.2.774-777.2006.
Abstract
Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log10) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.
摘要
用利巴韦林（40毫克/千克体重，每天腹腔注射两次）、皮质酮（在水中浓度为0.2毫克/毫升）或两种方式联合处理感染人偏肺病毒（hMPV）的BALB/c小鼠。与对照组相比，利巴韦林在感染后第5天显著降低了肺中hMPV的复制（降低5个对数10）以及整体肺部炎症，而糖皮质激素仅减轻了肺泡和间质炎症。
相似文献
1
Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.利巴韦林与糖皮质激素治疗对人偏肺病毒感染小鼠模型的影响。
Antimicrob Agents Chemother. 2006 Feb;50(2):774-7. doi: 10.1128/AAC.50.2.774-777.2006.
2
Human metapneumovirus infection induces long-term pulmonary inflammation associated with airway obstruction and hyperresponsiveness in mice.人偏肺病毒感染可在小鼠中诱发与气道阻塞和高反应性相关的长期肺部炎症。
J Infect Dis. 2006 Jun 15;193(12):1634-42. doi: 10.1086/504262. Epub 2006 May 11.
3
Prophylactic and therapeutic benefits of a monoclonal antibody against the fusion protein of human metapneumovirus in a mouse model.抗人偏肺病毒融合蛋白单克隆抗体在小鼠模型中的预防和治疗作用。
Antiviral Res. 2010 Oct;88(1):31-7. doi: 10.1016/j.antiviral.2010.07.001. Epub 2010 Jul 7.
4
5
Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies.尽管存在中和抗体，人偏肺病毒仍可在BALB/c小鼠体内持续存在。
J Virol. 2004 Dec;78(24):14003-11. doi: 10.1128/JVI.78.24.14003-14011.2004.
6
Immune response and alteration of pulmonary function after primary human metapneumovirus (hMPV) infection of BALB/c mice.BALB/c小鼠初次感染人偏肺病毒（hMPV）后的免疫反应及肺功能改变
Vaccine. 2005 Aug 22;23(36):4473-80. doi: 10.1016/j.vaccine.2005.04.027.
7
Treatment with oral ribavirin and IVIG of severe human metapneumovirus pneumonia (HMPV) in immune compromised child.免疫功能低下儿童严重人偏肺病毒肺炎（HMPV）的口服利巴韦林和静脉注射免疫球蛋白治疗
Pediatr Blood Cancer. 2011 Aug;57(2):350-1. doi: 10.1002/pbc.23019.
8
9
Immune modulatory activity of ribavirin for serious human metapneumovirus disease: early i.v. therapy may improve outcomes in immunosuppressed SCT recipients.
Bone Marrow Transplant. 2008 Apr;41(8):707-8. doi: 10.1038/bmt.2008.80. Epub 2008 Mar 17.
10
Treatment of severe human metapneumovirus (hMPV) pneumonia in an immunocompromised child with oral ribavirin and IVIG.用口服利巴韦林和静脉注射免疫球蛋白治疗一名免疫功能低下儿童的严重人偏肺病毒（hMPV）肺炎。
J Pediatr Hematol Oncol. 2013 Oct;35(7):e311-3. doi: 10.1097/MPH.0b013e3182915d2d.
引用本文的文献
1
Human Metapneumovirus: A Narrative Review on Emerging Strategies for Prevention and Treatment.人偏肺病毒：预防与治疗新策略的叙述性综述
Viruses. 2025 Aug 20;17(8):1140. doi: 10.3390/v17081140.
2
Clinical Insights and Advancements in Human Metapneumovirus Management and Prognosis.人偏肺病毒管理与预后的临床见解及进展
Discoveries (Craiova). 2025 Mar 31;13(1):e204. doi: 10.15190/d.2025.3. eCollection 2025 Jan-Mar.
3
Interplay between endogenous hormones and immune systems in human metapneumovirus pathogenesis and management.人偏肺病毒发病机制及治疗中内源性激素与免疫系统之间的相互作用
Front Pharmacol. 2025 Mar 19;16:1568828. doi: 10.3389/fphar.2025.1568828. eCollection 2025.
4
Respiratory illness virus infections with special emphasis on COVID-19.呼吸道疾病病毒感染，特别强调 COVID-19。
Eur J Med Res. 2022 Nov 8;27(1):236. doi: 10.1186/s40001-022-00874-x.
5
Status presens of antiviral drugs and strategies: Part II: RNA VIRUSES (EXCEPT RETROVIRUSES).抗病毒药物现状与策略：第二部分：RNA病毒（逆转录病毒除外）
Adv Antivir Drug Des. 2007;5:59-112. doi: 10.1016/S1075-8593(06)05002-7. Epub 2007 Sep 2.
6
Prophylactic and therapeutic approaches for human metapneumovirus.人偏肺病毒的预防和治疗方法。
Virusdisease. 2018 Dec;29(4):434-444. doi: 10.1007/s13337-018-0498-5. Epub 2018 Oct 20.
7
Community-Acquired Respiratory Paramyxovirus Infection After Allogeneic Hematopoietic Cell Transplantation: A Single-Center Experience.异基因造血细胞移植后社区获得性呼吸道副粘病毒感染：单中心经验
Open Forum Infect Dis. 2018 Apr 12;5(5):ofy077. doi: 10.1093/ofid/ofy077. eCollection 2018 May.
8
Human metapneumovirus - what we know now.人偏肺病毒——我们目前所了解的情况。
F1000Res. 2018 Feb 1;7:135. doi: 10.12688/f1000research.12625.1. eCollection 2018.
9
Severe Respiratory Viral Infections: New Evidence and Changing Paradigms.严重呼吸道病毒感染：新证据与不断变化的范式
Infect Dis Clin North Am. 2017 Sep;31(3):455-474. doi: 10.1016/j.idc.2017.05.004. Epub 2017 Jul 5.
10
Burden of human metapneumovirus infections in patients with cancer: Risk factors and outcomes.癌症患者中人间偏肺病毒感染的负担：危险因素与结局
Cancer. 2017 Jun 15;123(12):2329-2337. doi: 10.1002/cncr.30599. Epub 2017 Feb 8.
本文引用的文献
1
The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity.棉鼠（棉鼠属）是人类偏肺病毒感染、发病机制及保护性免疫的一种适宜的小动物模型。
J Virol. 2005 Sep;79(17):10944-51. doi: 10.1128/JVI.79.17.10944-10951.2005.
2
Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease.社区获得性肺炎和慢性阻塞性肺疾病加重的成人患者中的人偏肺病毒感染
Clin Infect Dis. 2005 Aug 15;41(4):498-502. doi: 10.1086/431981. Epub 2005 Jul 15.
3
Pathogenesis of human metapneumovirus lung infection in BALB/c mice and cotton rats.人偏肺病毒在BALB/c小鼠和棉鼠肺部感染的发病机制
J Virol. 2005 Jul;79(14):8894-903. doi: 10.1128/JVI.79.14.8894-8903.2005.
4
Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccines.建立棉鼠-人偏肺病毒（hMPV）模型以鉴定和评估潜在的hMPV抗病毒药物及疫苗。
Antiviral Res. 2005 Apr;66(1):57-66. doi: 10.1016/j.antiviral.2004.12.009.
5
Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies.尽管存在中和抗体，人偏肺病毒仍可在BALB/c小鼠体内持续存在。
J Virol. 2004 Dec;78(24):14003-11. doi: 10.1128/JVI.78.24.14003-14011.2004.
6
Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design.鉴定用于评估人偏肺病毒（hMPV）候选疫苗的小动物和灵长类动物模型及其对hMPV疫苗设计的意义。
J Gen Virol. 2004 Jun;85(Pt 6):1655-1663. doi: 10.1099/vir.0.79805-0.
7
Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice.呼吸道合胞病毒可诱发小鼠肺炎、细胞因子反应、气道阻塞以及与长期气道高反应性相关的慢性炎性浸润。
J Infect Dis. 2004 May 15;189(10):1856-65. doi: 10.1086/386372. Epub 2004 Apr 29.
8
Human metapneumovirus: a new player among respiratory viruses.人偏肺病毒：呼吸道病毒中的新成员。
Clin Infect Dis. 2004 Apr 1;38(7):983-90. doi: 10.1086/382536. Epub 2004 Mar 15.
9
Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro.利巴韦林和免疫血清球蛋白在体外对人偏肺病毒和呼吸道合胞病毒抑制作用的比较。
Antiviral Res. 2003 Sep;60(1):51-9. doi: 10.1016/s0166-3542(03)00153-0.
10
Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups.与人类偏肺病毒相关的病毒学特征及临床表现：一种可导致各年龄组急性呼吸道感染的新型副粘病毒
J Infect Dis. 2002 Nov 1;186(9):1330-4. doi: 10.1086/344319. Epub 2002 Oct 8.
Zotero 插件