来自乌拉圭肠炎沙门氏菌德比分离株质粒的新型透射电镜衍生超广谱β-内酰胺酶及其基因组背景
New TEM-derived extended-spectrum beta-lactamase and its genomic context in plasmids from Salmonella enterica serovar derby isolates from Uruguay.
作者信息
Vignoli Rafael, Cordeiro Nicolas F, García Virginia, Mota María Inés, Betancor Laura, Power Pablo, Chabalgoity José A, Schelotto Felipe, Gutkind Gabriel, Ayala Juan A
机构信息
Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, 11600 Montevideo, Uruguay.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):781-4. doi: 10.1128/AAC.50.2.781-784.2006.
Abstract
A small (8.2-kb) ColE1 plasmid encoding TEM-144 (a new beta-lactamase with a ceftazidimase profile) was sequenced by a gene-walking strategy. The bla(TEM) allele was carried on a Tn2 element, disrupting a Rom protein gene. TEM-144 differs from TEM-1 by two mutations (R164C and E240K) and from the ceftazidime-hydrolyzing TEM-91 by one mutation (T182M).
摘要
通过基因步移策略对一个编码TEM-144（一种具有头孢他啶酶谱的新型β-内酰胺酶）的小型（8.2 kb）ColE1质粒进行了测序。bla(TEM)等位基因位于Tn2元件上，破坏了一个Rom蛋白基因。TEM-144与TEM-1有两个突变（R164C和E240K）不同，与水解头孢他啶的TEM-91有一个突变（T182M）不同。
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