MacKenzie Ellen J, Rivara Frederick P, Jurkovich Gregory J, Nathens Avery B, Frey Katherine P, Egleston Brian L, Salkever David S, Scharfstein Daniel O
Johns Hopkins Bloomberg School of Public Health, Center for Injury Research and Policy, Baltimore, MD 21205-1996, USA.
N Engl J Med. 2006 Jan 26;354(4):366-78. doi: 10.1056/NEJMsa052049.
Hospitals have difficulty justifying the expense of maintaining trauma centers without strong evidence of their effectiveness. To address this gap, we examined differences in mortality between level 1 trauma centers and hospitals without a trauma center (non-trauma centers).
Mortality outcomes were compared among patients treated in 18 hospitals with a level 1 trauma center and 51 hospitals non-trauma centers located in 14 states. Patients 18 to 84 years old with a moderate-to-severe injury were eligible. Complete data were obtained for 1104 patients who died in the hospital and 4087 patients who were discharged alive. We used propensity-score weighting to adjust for observable differences between patients treated at trauma centers and those treated at non-trauma centers.
After adjustment for differences in the case mix, the in-hospital mortality rate was significantly lower at trauma centers than at non-trauma centers (7.6 percent vs. 9.5 percent; relative risk, 0.80; 95 percent confidence interval, 0.66 to 0.98), as was the one-year mortality rate (10.4 percent vs. 13.8 percent; relative risk, 0.75; 95 percent confidence interval, 0.60 to 0.95). The effects of treatment at a trauma center varied according to the severity of injury, with evidence to suggest that differences in mortality rates were primarily confined to patients with more severe injuries.
Our findings show that the risk of death is significantly lower when care is provided in a trauma center than in a non-trauma center and argue for continued efforts at regionalization.
在缺乏有力证据证明其有效性的情况下,医院很难证明维持创伤中心的费用是合理的。为了填补这一空白,我们研究了一级创伤中心与无创伤中心的医院(非创伤中心)在死亡率方面的差异。
比较了位于14个州的18家设有一级创伤中心的医院和51家非创伤中心医院中接受治疗的患者的死亡率。年龄在18至84岁之间、有中度至重度损伤的患者符合条件。获得了1104例在医院死亡患者和4087例存活出院患者的完整数据。我们使用倾向得分加权法来调整创伤中心治疗的患者与非创伤中心治疗的患者之间的可观察差异。
在调整病例组合差异后,创伤中心的院内死亡率显著低于非创伤中心(7.6%对9.5%;相对风险,0.80;95%置信区间,0.66至0.98),一年死亡率也是如此(10.4%对13.8%;相对风险,0.75;95%置信区间,0.60至0.95)。创伤中心治疗的效果因损伤严重程度而异,有证据表明死亡率差异主要局限于伤势较重的患者。
我们的研究结果表明,在创伤中心接受治疗时死亡风险显著低于非创伤中心,并支持继续推进区域化努力。