Sabir Nasim, Zafar Afia
Department of Pathology and Microbiology, The Aga Khan University, Karachi, Pakistan.
J Pak Med Assoc. 2005 Dec;55(12):560-1.
Shigellosis is an important public health problem, especially in developing countries. Antibiotic treatment of dysentery aimed at resolving diarrhea or reducing its duration, and to prevent transmission to other close contacts. Isolates with resistance to first line drugs have been reported throughout world, third generation cephalosporins and quinolones are mainstay of treatment. Shigella flexneri resistant to third generation cephalosporins in a clinical isolate is a rare finding, and this has been reported for the first time in Pakistan.
志贺氏菌病是一个重要的公共卫生问题，在发展中国家尤为如此。针对痢疾的抗生素治疗旨在缓解腹泻或缩短其持续时间，并防止传播给其他密切接触者。世界各地均有对一线药物耐药的分离株报告，第三代头孢菌素和喹诺酮类药物是治疗的主要手段。临床分离出的对第三代头孢菌素耐药的福氏志贺菌是一个罕见的发现，这在巴基斯坦尚属首次报道。
