Bilwani Fareena, Kakepoto Ghulam Nabi, Adil Salman N, Usman Mohammad, Hassan Farrukh, Khurshid Mohammad
Department of Pathology, The Aga Khan University Hospital, Karachi, Pakistan.
J Pak Med Assoc. 2005 Dec;55(12):563-5.
To provide frequency and distribution pattern of various types of irregular red cell alloantibodies in patients with thalassemia major.
This is a descriptive study conducted at two centers from January to December 2001. Purposive sampling was done and all patients diagnosed to have thalassemia major were included in the study. Antibody identification was carried out on serum employing commercial two-cell panel using standardized blood bank methods. If patients were found to have an irregular red cell alloantibody then the antibody identification was performed using 16 panel cells.
A total of ninety-seven patients were included in the study. Fifty-three patients were males and 44 females. Mean age was 10.6 years. Irregular red cell alloantibodies were found in 9 (9.2%). Mean age of patients who developed red cell alloantibody was 11.9 years. Three (33.3%) patients developed anti-K while two (22.2%) had non-specific antibody. One patient each developed anti-D (11.1%) and anti-E (11.1%). Two had anti-D (11.1%) and anti-C while the other one (11.1%) developed anti-E and anti-K.
We concluded that there is relatively high rate of alloimmunization in our set of patients when compared to data from our region. We also suggest that red cell alloimmunization should not be overlooked in patients receiving regular blood transfusions.
提供重型地中海贫血患者中各类不规则红细胞同种抗体的发生率及分布模式。
这是一项于2001年1月至12月在两个中心开展的描述性研究。采用目的抽样法，纳入所有确诊为重型地中海贫血的患者。运用标准化血库方法，使用商用双细胞板对血清进行抗体鉴定。若患者被发现有不规则红细胞同种抗体，则使用16细胞板进行抗体鉴定。
本研究共纳入97例患者。其中男性53例，女性44例。平均年龄为10.6岁。9例（9.2%）患者发现有不规则红细胞同种抗体。出现红细胞同种抗体的患者平均年龄为11.9岁。3例（33.3%）患者产生了抗-K抗体，2例（22.2%）有非特异性抗体。各有1例患者产生了抗-D（11.1%）和抗-E（11.1%）抗体。2例患者产生了抗-D（11.1%）和抗-C抗体，另1例（11.1%）产生了抗-E和抗-K抗体。
我们得出结论，与本地区数据相比，我们所研究的患者中同种免疫发生率相对较高。我们还建议，对于接受定期输血的患者，不应忽视红细胞同种免疫情况。
