Montaño Velázquez Bertha Beatriz, Jáuregui-Renaud Kathrine, Bañuelos Arias Alejandra del Carmen, Ayala Julio Cesar, Martínez Maria Dolores Mogica, Campillo Navarrete Ramón, Rosalia Isabel Silvia Vera, Salazar María del Refugio Cisneros, Serrano Horacio Alfonso Castilla, Mondragón Alicia Ocaña, Perez Rosendo Luria
Unidad de Investigación Médica, Hospital General, Centro Médico Nacional La Raza, IMSS, México, Distrito Federal.
Ann Allergy Asthma Immunol. 2006 Jan;96(1):45-50. doi: 10.1016/s1081-1206(10)61039-3.
Studies have shown that vitamin E intake may reduce IgE production.
To evaluate the effects of vitamin E supplementation on the severity of nasal symptoms and the serum levels of specific IgE in patients with perennial allergic rhinitis.
Sixty-three patients (mean +/- SD age, 12 +/- 2.4 years) with a history of perennial allergic rhinitis participated in this study. None of the patients had evidence of acute infectious disease or used tobacco, corticosteroids, antihistamines, or vitamins. Patients were randomized to receive either vitamin E (400 IU/d) or placebo for 4 weeks, with loratadine-pseudoephedrine (0.2/0.5 mg/kg) during the first 2 weeks of treatment. The severity of nasal symptoms was evaluated using a validated questionnaire, which was administered weekly for 4 weeks. The serum concentrations of specific IgE to 5 common inhalant allergens and lipid peroxides were measured before treatment and at the end of the study.
Before, during, and after treatment, the symptom severity scores were similar in the 2 groups; within each group, a significant decrease was observed after the first week of follow-up (P < .05), with no further changes. Serum levels of specific IgE and lipid peroxides did not show any significant changes related to vitamin E intake within and between groups.
In patients with perennial allergic rhinitis, vitamin E supplementation (400 IU/d) did not have any significant effects on nasal symptom severity or on serum concentrations of specific IgE to 5 common allergens.
研究表明，摄入维生素E可能会减少免疫球蛋白E（IgE）的产生。
评估补充维生素E对常年性变应性鼻炎患者鼻部症状严重程度及特异性IgE血清水平的影响。
63例有常年性变应性鼻炎病史的患者（平均年龄±标准差，12±2.4岁）参与了本研究。所有患者均无急性传染病证据，且未使用烟草、皮质类固醇、抗组胺药或维生素。患者被随机分为两组，一组接受维生素E（400 IU/天），另一组接受安慰剂，为期4周，治疗的前2周同时服用氯雷他定-伪麻黄碱（0.2/0.5 mg/kg）。使用经过验证的问卷评估鼻部症状的严重程度，该问卷在4周内每周发放一次。在治疗前和研究结束时测量血清中针对5种常见吸入性变应原的特异性IgE浓度和脂质过氧化物水平。
治疗前、治疗期间和治疗后，两组的症状严重程度评分相似；在每组中，随访第一周后症状严重程度评分显著降低（P <.05），之后无进一步变化。组内和组间，血清特异性IgE水平和脂质过氧化物水平与维生素E摄入均无显著相关变化。
在常年性变应性鼻炎患者中，补充维生素E（400 IU/天）对鼻部症状严重程度或血清中针对5种常见变应原的特异性IgE浓度均无显著影响。
