Wang Shi-Yi, Wang Yin-Feng, Pan Chun-Chen, Sun Jing-Wu
Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China.
Department of Otolaryngology-Head and Neck Surgery, Anhui Provincial Hospital Affiliated Anhui Medical University, No. 17 Lujiang Road, Hefei, Anhui Province, 230001, People's Republic of China.
BMC Pediatr. 2020 Jul 31;20(1):362. doi: 10.1186/s12887-020-02248-w.
Allergic rhinitis (AR) is one of the most prevalent allergic diseases in children. This study aimed to investigate the association between serum concentrations of vitamin E and AR to determine if the vitamin E level is correlated with the occurrence and severity of AR.
A total of 113 children were enrolled in this cross-sectional study. Sixty-five children in the outpatient group were diagnosed with AR, and 48 healthy children were recruited as controls. All subjects underwent serum vitamin E (adjusted for total cholesterol and triglycerides) measurements. Serum to total IgE (tIgE), the five most common allergen-specific IgE (sIgE) levels and skin prick test (SPT) were measured in children with AR. The severity of AR was assessed with the nasal symptoms score, and the situation of exposure to passive smoking were inquired.
Serum vitamin E levels were significantly lower in the AR group than in the normal children (P < 0.001). A significant negative correlation was observed between serum vitamin E levels and sIgE as well as the SPT grade. Serum vitamin E levels were also inversely related to the nasal symptoms score; however, statistical significance was not found.
A significantly lower vitamin E level was found in children with AR. Lower serum vitamin E levels may have correlation with the occurrence of AR in children. However, serum vitamin E levels were not statistically correlated with the severity of AR.
过敏性鼻炎（AR）是儿童中最常见的过敏性疾病之一。本研究旨在调查血清维生素E浓度与AR之间的关联，以确定维生素E水平是否与AR的发生和严重程度相关。
共有113名儿童纳入本横断面研究。门诊组65名儿童被诊断为AR，48名健康儿童作为对照。所有受试者均接受血清维生素E（校正总胆固醇和甘油三酯后）检测。对AR患儿检测血清总IgE（tIgE）、五种最常见的过敏原特异性IgE（sIgE）水平及皮肤点刺试验（SPT）。采用鼻症状评分评估AR的严重程度，并询问被动吸烟暴露情况。
AR组血清维生素E水平显著低于正常儿童（P＜0.001）。血清维生素E水平与sIgE及SPT分级之间存在显著负相关。血清维生素E水平也与鼻症状评分呈负相关，但未发现统计学意义。
AR患儿的维生素E水平显著降低。较低的血清维生素E水平可能与儿童AR的发生有关。然而，血清维生素E水平与AR的严重程度无统计学相关性。
