Hayaran A, Wadhwa S, Gopinath G, Bijlani V
Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
Exp Brain Res. 1992;89(3):640-8. doi: 10.1007/BF00229888.
Histological and quantitative studies were carried out in dentate nucleus (DN) of 14 human fetuses of gestational ages ranging from 10 weeks to 28 weeks in Nissl stained sections. The dentate nucleus was already well delineated at 11 weeks, but the adult profile was attained only by 27-28 weeks. The magnocellular dorsomedial region and the parvocellular ventrolateral region became apparent at 17-18 weeks. The numerical density of neurons showed a steady decline with advancing gestational age. However, the absolute neuronal count until 19-20 weeks was 367.1 x 10(3) followed by a count of 249.5 x 10(3) at 22-23 weeks. The reduction in the count between the two periods was significant and coincided with cell death which was striking between 19 and 23 weeks. The glial cell population continued to increase with advancing gestational age. The occurrence of significant neuronal cell death and its probable role in the developing human DN is reported for the first time.
对14例孕龄在10周龄至28周龄的人类胎儿齿状核（DN）进行了组织学和定量研究，采用尼氏染色切片。齿状核在11周龄时已清晰可辨，但直到27 - 28周龄才达到成人形态。大细胞背内侧区和小细胞腹外侧区在17 - 18周龄时变得明显。神经元的数值密度随着孕龄增加而稳步下降。然而，直到19 - 20周龄时神经元绝对计数为367.1×10³，在22 - 23周龄时为249.5×10³。这两个时期之间计数的减少是显著的，并且与19至23周龄时显著的细胞死亡相吻合。神经胶质细胞数量随着孕龄增加而持续增加。首次报道了人类发育中齿状核显著神经元细胞死亡的发生及其可能作用。
