Farrell S, Ide M, Wilson R F
King's College London, Dental Institute, Periodontology London, UK.
J Clin Periodontol. 2006 Feb;33(2):115-20. doi: 10.1111/j.1600-051X.2005.00884.x.
It has been postulated that associations between periodontal disease and systemic conditions may be because of the confounding effects of smoking. In addition, studies of this type rarely investigate the adverse pregnancy outcome of miscarriage.
The aim of this prospective study was to investigate a relationship between periodontal disease in pregnancy and subsequent adverse pregnancy outcomes in a population of never smokers.
Pregnant women were recruited at 12 weeks gestation. Demographic, behavioural and medical data were collected. A periodontal examination was performed and data on each subjects' pregnancy outcome were collected.
A total of 1793 women reported never previously smoking. Of these, 7.3% had a pre-term birth and 0.9% a late miscarriage. As expected in this population, we found no associations between poorer periodontal health and either pre-term birth or low birth weight (LBW). In contrast, the subjects who experienced a late miscarriage had a higher mean probing depth at mesial sites compared with the subjects that gave birth at term (2.69 mm versus 2.41 mm, p=0.006).
There was an association between some measures of periodontal disease and late miscarriage; however, there was no association between periodontitis and pre-term birth or LBW in this population.
据推测，牙周疾病与全身状况之间的关联可能是由于吸烟的混杂效应。此外，这类研究很少调查流产这种不良妊娠结局。
这项前瞻性研究的目的是在从不吸烟的人群中调查孕期牙周疾病与随后不良妊娠结局之间的关系。
在妊娠12周时招募孕妇。收集人口统计学、行为学和医学数据。进行牙周检查并收集每个受试者的妊娠结局数据。
共有1793名女性报告既往从不吸烟。其中，7.3%发生早产，0.9%发生晚期流产。正如在该人群中所预期的，我们发现牙周健康状况较差与早产或低出生体重之间无关联。相比之下，与足月分娩的受试者相比，经历晚期流产的受试者在近中位点的平均探诊深度更高（2.69毫米对2.41毫米，p = 0.006）。
牙周疾病的某些指标与晚期流产之间存在关联；然而，在该人群中牙周炎与早产或低出生体重之间无关联。
