Suba Zsuzsanna, Takács Daniel, Matusovits Danica, Barabás József, Fazekas András, Szabó György
Department of Oral and Maxillofacial Surgery, Semmelweis University, Budapest, Hungary.
Clin Oral Implants Res. 2006 Feb;17(1):102-8. doi: 10.1111/j.1600-0501.2005.01166.x.
Graft insertion can effectively enhance the regeneration of debilitated bone. The effects of an alloplastic bone-replacing material, beta-tricalcium phosphate (Cerasorb), and of autogenous bone graft were compared.
In 17 edentulous patients, the maxillary sinus floor was extremely atrophied to such an extent that implant placement was impossible. The Schneiderian membrane was surgically elevated bilaterally by insertion of Cerasorb (experimental side) and autogenous bone graft (control side). After surgery, the recovery was followed clinically and radiologically. After 6 months, 68 bone cylinders were excised from the grafted areas and implants were inserted into their places. The bone samples were embedded into resin, and the osteointegration of the grafts was studied histologically. Trabecular bone volume (TBV) and trabecular bone pattern factor (TBPf) were quantified by histomorphometry.
Cerasorb proved to be an effective bone-replacing material with osteoconductivity; it was capable of gradual disintegration, thereby providing space for the regenerating bone. The new bone density was not significantly different on the experimental and control sides (32.4+/-10.9% and 34.7+/-11.9%, respectively). However, the graft biodegradation was significantly slower on the experimental side than the control side. The TBPf value was lower on the control side than on the experimental side (-0.53+/-1.7 and -0.11+/-1.4 mm(-1), respectively), but this difference was not significant.
Six months after insertion of the grafts, the bone of the augmented sinus floor was strong and suitable for anchorage of dental implants, irrespective of whether autogenous bone or Cerasorb particles had been applied.
植入物植入可有效促进衰弱骨的再生。比较了一种异体骨替代材料β - 磷酸三钙（Cerasorb）和自体骨移植的效果。
17例无牙患者，上颌窦底极度萎缩，无法植入种植体。通过双侧手术植入Cerasorb（实验组）和自体骨移植（对照组）来抬高施耐德膜。术后，进行临床和影像学随访。6个月后，从移植区域取出68个骨圆柱体，并在其位置植入种植体。将骨样本嵌入树脂中，组织学研究移植物的骨整合情况。通过组织形态计量学对小梁骨体积（TBV）和小梁骨模式因子（TBPf）进行量化。
Cerasorb被证明是一种具有骨传导性的有效骨替代材料；它能够逐渐分解，从而为再生骨提供空间。实验组和对照组的新骨密度无显著差异（分别为32.4±10.9%和34.7±11.9%）。然而，实验组的移植物生物降解明显慢于对照组。对照组的TBPf值低于实验组（分别为-0.53±-1.7和-0.11±-1.4 mm-1），但这种差异不显著。
移植后6个月，无论应用的是自体骨还是Cerasorb颗粒，上颌窦底增高部位的骨都坚固且适合牙种植体的锚固。
