Artzi Zvi, Kozlovsky Avital, Nemcovsky Carlos E, Weinreb Miron
Department of Periodontology, School of Dental Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 61390, Israel.
J Clin Periodontol. 2005 Feb;32(2):193-9. doi: 10.1111/j.1600-051X.2005.00656.x.
Bone replacement substitutes are almost unavoidable in augmentation procedures such as sinus grafting. The objective of the present study was to evaluate the osteoconductive capability of two different scaffold fillers in inducing newly formed bone in this procedure.
Sinus floor augmentation and implant placement were carried out bilaterally in 12 patients. Bovine bone mineral (BBM) was grafted on one side and beta-tricalcium phosphate (beta-TCP) on the contralateral side. Both were mixed (1:1 ratio) with autogenous cortical bone chips harvested from the mandible by a scraper. Hard tissue specimen cores were retrieved from the augmented sites (at the previous window area) at 12 months. Decalcified sections were stained with haematoxylin-eosin and the fraction area of new bone and filler particles was measured. In addition to the effect of the filler on new bone formation, the latter was tested to determine whether it correlated with the tissue depth and residual amount of the grafted material.
Bone area fraction increased significantly from peripheral to deeper areas at both grafted sites in all cores: from 26.0% to 37.7% at the beta-TCP sites and from 33.5% to 53.7% at the BBM-grafted sites. At each depth the amount of new bone in BBM sites was significantly greater than that in TCP sites. However, the average area fraction of grafted material particles was similar in both fillers and all depth levels (beta-TCP=27.9-23.2% and BBM=29.2-22.6%, NS). A significant negative correlation was found between bone area fraction and particle area fraction at the middle (p=0.009) and deep (p=0.014) depths in the beta-TCP sites, but not at the BBM sites.
At 12 months post-augmentation, the two examined bone fillers, beta-TCP and BBM, promoted new bone formation in sinus grafting but the amount of newly formed bone was significantly greater in BBM-grafted sites. However, both exhibited similar residual grafted material area fraction at this healing period. This could imply that BBM possesses better osteoconductive properties.
在诸如鼻窦植骨等增量手术中，骨替代物几乎是不可避免的。本研究的目的是评估两种不同支架填充物在该手术中诱导新形成骨的骨传导能力。
对12例患者双侧进行鼻窦底增高和种植体植入。一侧植入牛骨矿物质（BBM），对侧植入β-磷酸三钙（β-TCP）。两者均与用刮匙从下颌骨采集的自体皮质骨屑按1:1比例混合。在12个月时从增高部位（先前开窗区域）获取硬组织标本芯。脱钙切片用苏木精-伊红染色，测量新骨和填充物颗粒的面积分数。除了填充物对新骨形成的影响外，还测试新骨形成是否与组织深度和移植材料的剩余量相关。
在所有芯样的两个移植部位，骨面积分数从周边到深部区域均显著增加：β-TCP部位从26.0%增至37.7%，BBM移植部位从33.5%增至53.7%。在每个深度，BBM部位的新骨量均显著大于TCP部位。然而，两种填充物在所有深度水平的移植材料颗粒平均面积分数相似（β-TCP = 27.9 - 23.2%，BBM = 29.2 - 22.6%，无显著性差异）。在β-TCP部位的中部（p = 0.009）和深部（p = 0.014）深度，骨面积分数与颗粒面积分数之间存在显著负相关，但在BBM部位不存在。
增高术后12个月，所检测的两种骨填充物β-TCP和BBM均促进了鼻窦植骨中的新骨形成，但BBM移植部位新形成的骨量显著更多。然而，在这个愈合期，两者的移植材料剩余面积分数相似。这可能意味着BBM具有更好的骨传导特性。
Zotero 插件