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扁桃体大小和体重指数是影响单纯扁桃体切除术治疗阻塞性睡眠呼吸暂停综合征疗效的重要因素。

Tonsil size and body mass index are important factors for efficacy of simple tonsillectomy in obstructive sleep apnoea syndrome.

作者信息

Nakata S, Noda A, Yanagi E, Suzuki K, Yamamoto H, Nakashima T

机构信息

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Clin Otolaryngol. 2006 Feb;31(1):41-5. doi: 10.1111/j.1749-4486.2006.01130.x.

Abstract

OBJECTIVES

To evaluate the efficacy of simple tonsillectomy to treat obstructive sleep apnoea syndrome (OSAS) in adults.

DESIGN

Prospective study.

SETTING

Tertiary referral centre.

PARTICIPANTS

Thirty patients (28 males) underwent simple tonsillectomy under general anaesthesia. The patients' mean age was 33.2 +/- 6.8 years and body mass index was 30.7 +/- 6.0 kg/m2. Seven patients (23%) were classified with grade 4, 16 patients (53%) with grade 3, and seven patients (23%) with grade 2 according to the tonsil size of Friedman's classification.

MAIN OUTCOME MEASURES

The number of apnoea episodes per hour (apnoea index), the number of apnoea and hypopnoea episodes per hour (apnoea-hypopnoea index), lowest nocturnal oxygen saturation and oxygen desaturation time were measured during overnight polysomnography before and after surgery. A successful tonsillectomy was defined as an apnoea-hypopnoea index improvement ratio of > or =50% and an apnoea-hypopnoea index <20 after operation.

RESULTS

Apnoea-hypopnoea index decreased from 69.0 +/- 28.4/h to 30.1 +/- 24.0/h (P < 0.0001). Simple tonsillectomy was successful in all six patients with body mass index <25 kg/m2. Concerning success rate of simple tonsillectomy with tonsil, size 2 was lowest (42.9%). Eight of the 13 patients who used continuous positive airway pressure before simple tonsillectomy did not use continuous positive airway pressure after simple tonsillectomy because of a significant reduction of excessive daytime sleepiness. Continuous positive airway pressure decreased significantly after simple tonsillectomy from 13.6 +/- 2.5 cmH2O preoperatively to 10.6 +/- 1.3 cmH2O postoperatively (P < 0.05).

CONCLUSIONS

These data suggest that simple tonsillectomy is a beneficial modality to treat OSAS in selected patients (larger tonsil, low body mass index), even in adults.

摘要

目的

评估单纯扁桃体切除术治疗成人阻塞性睡眠呼吸暂停综合征(OSAS)的疗效。

设计

前瞻性研究。

地点

三级转诊中心。

参与者

30例患者(28例男性)在全身麻醉下接受单纯扁桃体切除术。患者的平均年龄为33.2±6.8岁,体重指数为30.7±6.0kg/m²。根据Friedman分类法的扁桃体大小,7例患者(23%)为4级,16例患者(53%)为3级,7例患者(23%)为2级。

主要观察指标

在手术前后的夜间多导睡眠图检查中,测量每小时的呼吸暂停发作次数(呼吸暂停指数)、每小时的呼吸暂停和低通气发作次数(呼吸暂停-低通气指数)、最低夜间血氧饱和度和氧饱和度下降时间。成功的扁桃体切除术定义为术后呼吸暂停-低通气指数改善率≥50%且呼吸暂停-低通气指数<20。

结果

呼吸暂停-低通气指数从69.0±28.4次/小时降至30.1±24.0次/小时(P<0.0001)。所有体重指数<25kg/m²的6例患者单纯扁桃体切除术均成功。关于扁桃体大小为2级的单纯扁桃体切除术成功率最低(42.9%)。13例在单纯扁桃体切除术前行持续气道正压通气的患者中,有8例在单纯扁桃体切除术后因白天过度嗜睡明显减轻而未再使用持续气道正压通气。单纯扁桃体切除术后,持续气道正压通气从术前的13.6±2.5cmH₂O显著降至术后的10.6±1.3cmH₂O(P<0.05)。

结论

这些数据表明,即使在成人中,单纯扁桃体切除术对于特定患者(扁桃体较大、体重指数较低)治疗OSAS也是一种有益的方式。

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