Ferdinand Keith C
Heartbeats Life Center and Department of Clinical Pharmacology, Xavier University College of Pharmacy, New Orleans, Louisiana, USA.
Am J Cardiol. 2006 Jan 16;97(2A):12A-19A. doi: 10.1016/j.amjcard.2005.11.011. Epub 2005 Dec 1.
Racial/ethnic minorities in the United States have a risk for coronary artery disease (CAD) that is at least equivalent to that in the white majority. African Americans have greater cardiovascular mortality rates and greater risk for early mortality caused by CAD. Risk may be associated with a greater clustering of risk factors in African Americans and other minority groups and may be associated with inadequate screening and evidence-based treatment of these groups in clinical practice. Data are beginning to emerge showing racial/ethnic variation in levels of the inflammatory marker high-sensitivity C-reactive protein, with higher levels in African Americans than in whites. There remain significant challenges to understanding racial/ethnic differences in cardiovascular risk factors and to including minority groups in clinical trials of therapeutic interventions, thereby ensuring optimal treatment for all.
美国的种族/族裔少数群体患冠状动脉疾病（CAD）的风险至少与白人多数群体相当。非裔美国人的心血管死亡率更高，因CAD导致早期死亡的风险也更大。风险可能与非裔美国人和其他少数群体中风险因素的聚集程度更高有关，也可能与临床实践中对这些群体的筛查不足和缺乏循证治疗有关。有数据开始显示，炎症标志物高敏C反应蛋白水平存在种族/族裔差异，非裔美国人的水平高于白人。在理解心血管风险因素的种族/族裔差异以及将少数群体纳入治疗干预临床试验从而确保所有人都能获得最佳治疗方面，仍然存在重大挑战。
