老年与中年胃癌患者手术结局的比较
Comparison of surgical outcomes of gastric cancer in elderly and middle-aged patients.
作者信息
Kunisaki Chikara, Akiyama Hirotoshi, Nomura Masato, Matsuda Goro, Otsuka Yuichi, Ono Hidetaka Andrew, Shimada Hiroshi
机构信息
Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
出版信息
Am J Surg. 2006 Feb;191(2):216-24. doi: 10.1016/j.amjsurg.2005.09.001.
BACKGROUND
We compared clinicopathological features and results of surgery for gastric carcinoma in elderly and middle-aged patients to develop appropriate treatment for elderly patients with gastric carcinoma.
METHODS
Surgical results were assessed for 135 elderly patients (over 75 years old) and 665 middle-aged patients (between 45 and 65 years old) with gastric cancer.
RESULTS
Distinct characteristics of elderly patients were male predominance; macroscopically well, or ill-defined, histologically differentiated tumors; and advanced stage disease. There was a significant difference in overall survival between the groups for early stage carcinomas but no difference in cause-specific survival. Postoperative morbidities did not differ between the curatively resected patients in the 2 groups. Moreover, deaths from other cancers or comorbid disease were frequent among the elderly.
CONCLUSION
Meticulous treatment and follow-up not only for gastric carcinoma but also for other diseases would improve survival in elderly patients, particularly those with early-stage tumors.
背景
我们比较了老年和中年胃癌患者的临床病理特征及手术结果，以便为老年胃癌患者制定合适的治疗方案。
方法
评估了135例老年（75岁以上）和665例中年（45至65岁）胃癌患者的手术结果。
结果
老年患者的显著特征为男性居多；宏观上肿瘤边界清晰或不清晰、组织学上分化良好的肿瘤；以及疾病处于晚期。两组早期癌患者的总生存率存在显著差异，但特定病因生存率无差异。两组根治性切除患者的术后发病率无差异。此外，老年患者中因其他癌症或合并症死亡的情况较为常见。
结论
不仅要对胃癌，还要对其他疾病进行细致的治疗和随访，这将提高老年患者的生存率，尤其是那些患有早期肿瘤的患者。
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